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Ak7
Gene Detail
Symbol

Name
ID
Ak7
adenylate kinase 7
MGI:1926051
Synonyms
4930502N02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
55.95 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:105705982-105782447 bp, + strand
From NCBI annotation of GRCm38

  76466 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14268  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ak7

Human
homologs
Human Homolog AK7, adenylate kinase 7
NCBI Gene ID 122481
neXtProt AC  NX_Q96M32
Human Synonyms  AK 7
Human Chr (Location)  14q32.2; chr14:96392111-96489427 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(183) : Gene trapped(182) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice exhibit hydrocephalus, rhinitis, sperm defects and most die before 8 weeks of age.
 
Human Diseases Modeled Using Mouse Ak7 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ak7 interacts with 114 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process axoneme assembly, brain development, ...
Component cytoplasm, nucleus
Function adenylate kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000041323 (Evidence)
Entrez Gene78801 (Evidence)
DFCITC1589257, TC1596392
DoTSDT.101291908, DT.101717839, DT.55170228
NIA Mouse Gene IndexU014347
EC2.7.4.3, 2.7.4.6
Consensus CDS ProjectCCDS49162.1
International Mouse Knockout Project StatusAk7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 78801 NCBI Gene Model | MGI Sequence Detail 76466 C57BL/6J ±  kb
transcript NM_030187 RefSeq | MGI Sequence Detail 3093 C57BL/6 
polypeptide Q9D2H2 UniProt | EBI | MGI Sequence Detail 614 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(7) UniProt(2)
Polymorphisms
SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000850 Adenylate kinase
InterPro IPR007858 Dpy-30 motif
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000029118 adenylate kinase 7
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(27)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory