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Nol3
Gene Detail
 Symbol
Name
ID
Nol3
nucleolar protein 3 (apoptosis repressor with CARD domain)
MGI:1925938
Synonyms ARC, B430311C09Rik, Nop30
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105276447-105281939 bp, + strand
From NCBI annotation of GRCm38

  5493 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nol3

Human
homologs
Human Homolog NOL3, nucleolar protein 3 (apoptosis repressor with CARD domain)
NCBI Gene ID 8996
neXtProt AC  NX_O60936
Human Synonyms  ARC, FCM, MYP, NOP, NOP30
Human Chr (Location)  16q22.1; chr16:67170497-67175737 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NOL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit accelerated cardiomyopathy in response to pressure overload and increased myocardial infarct size after I/R injury. Mice homozygous for another knock-out allele exhibit attenuated pulmonary hypertension and vasculature remodeling response to chronic hypoxia.
 
Interactions
Nol3 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mRNA processing, negative regulation of apoptotic process, ...
Component mitochondrion, nucleus, ...
Function identical protein binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (44)    Tissues (43)    Images (4)
Theiler Stages: 19, 20, 22, 24, 27, 28
Assay TypeResults
RNA in situ 34
RT-PCR 10
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000014776 (Evidence)
Entrez Gene78688 (Evidence)
NIA Mouse Gene IndexU009742
Consensus CDS ProjectCCDS52657.1
International Mouse Knockout Project StatusNol3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 78688 NCBI Gene Model | MGI Sequence Detail 5493 C57BL/6J ±  kb
transcript NM_030152 RefSeq | MGI Sequence Detail 2869 C57BL/6 
polypeptide Q9D1X0 UniProt | EBI | MGI Sequence Detail 220 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
Protein Ontology PR:000011310 nucleolar protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211017 Davis J, et al., Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. PLoS One. 2013;8(12):e82053
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory