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Nol3 Gene Detail
Summary
  • Symbol
    Nol3
  • Name
    nucleolar protein 3 (apoptosis repressor with CARD domain)
  • Synonyms
    ARC, B430311C09Rik, Nop30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925938
    NCBI Gene: 78688
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106002777-106008571 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925938
protein coding gene Chr8:106002772-106008571 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034034
protein coding gene Chr8:107541764-107547256 (+)
A/J MGP_AJ_G0034015
protein coding gene Chr8:103254406-103259727 (+)
AKR/J MGP_AKRJ_G0033941
protein coding gene Chr8:106238415-106243708 (+)
BALB/cJ MGP_BALBcJ_G0034008
protein coding gene Chr8:103429564-103434957 (+)
C3H/HeJ MGP_C3HHeJ_G0033720
protein coding gene Chr8:106984275-106990419 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034528
protein coding gene Chr8:111490950-111496457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031470
protein coding gene Chr8:96403955-96409199 (+)
CAST/EiJ MGP_CASTEiJ_G0033046
protein coding gene Chr8:106483223-106488650 (+)
CBA/J MGP_CBAJ_G0033693
protein coding gene Chr8:115088340-115093659 (+)
DBA/2J MGP_DBA2J_G0033848
protein coding gene Chr8:102598985-102604830 (+)
FVB/NJ MGP_FVBNJ_G0033794
protein coding gene Chr8:101522621-101528281 (+)
LP/J MGP_LPJ_G0033939
protein coding gene Chr8:107752889-107758183 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033837
protein coding gene Chr8:118301161-118306653 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034546
protein coding gene Chr8:106212401-106217893 (+)
PWK/PhJ MGP_PWKPhJ_G0032747
protein coding gene Chr8:101984186-101988843 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032588
protein coding gene Chr8:104889552-104894948 (+)
WSB/EiJ MGP_WSBEiJ_G0033162
protein coding gene Chr8:106865503-106870989 (+)



Homology
more
  • Human Ortholog
    NOL3, nucleolar protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOL3, nucleolar protein 3
  • Synonyms
    ARC, FCM, MYOCL1, MYP, NOP, NOP30
  • Links
    NCBI Gene ID: 8996
    neXtProt AC: NX_O60936
    UniProt: O60936

  • Chr Location
    16q22.1; chr16:67170154-67175737 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit accelerated cardiomyopathy in response to pressure overload and increased myocardial infarct size after I/R injury. Mice homozygous for another knock-out allele exhibit attenuated pulmonary hypertension and vasculature remodeling response to chronic hypoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78688 NCBI Gene Model | MGI Sequence Detail 5795 C57BL/6J ±  kb
    transcript NM_030152 RefSeq | MGI Sequence Detail 2869 ZRU/MplStud  
    polypeptide Q9D1X0 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:303708 McKimpson WM, et al., Conversion of the death inhibitor ARC to a killer activates pancreatic beta cell death in diabetes. Dev Cell. 2021 Mar 22;56(6):747-760.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory