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Mvp Gene Detail
Summary
  • Symbol
    Mvp
  • Name
    major vault protein
  • Synonyms
    2310009M24Rik, LRP, VAULT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925638
    NCBI Gene: 78388
  • Gene Overview
    MyGene.info: MVP
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126986860-127014594 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.26 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925638
protein coding gene Chr7:126986860-127014621 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033012
protein coding gene Chr7:131298539-131328021 (-)
A/J MGP_AJ_G0032995
protein coding gene Chr7:127814489-127842218 (-)
AKR/J MGP_AKRJ_G0032927
protein coding gene Chr7:131050171-131077901 (-)
BALB/cJ MGP_BALBcJ_G0033000
protein coding gene Chr7:127477436-127505640 (-)
C3H/HeJ MGP_C3HHeJ_G0032710
protein coding gene Chr7:130990166-131019522 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033506
protein coding gene Chr7:136402002-136433129 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030478
protein coding gene Chr7:129025218-129054661 (-)
CAST/EiJ MGP_CASTEiJ_G0032039
protein coding gene Chr7:122778370-122808401 (-)
CBA/J MGP_CBAJ_G0032683
protein coding gene Chr7:140990248-141021039 (-)
DBA/2J MGP_DBA2J_G0032835
protein coding gene Chr7:125788533-125816272 (-)
FVB/NJ MGP_FVBNJ_G0032788
protein coding gene Chr7:125639010-125667597 (-)
LP/J MGP_LPJ_G0032929
protein coding gene Chr7:132763452-132797530 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032820
protein coding gene Chr7:142156256-142186932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033525
protein coding gene Chr7:130064485-130094520 (-)
PWK/PhJ MGP_PWKPhJ_G0031746
protein coding gene Chr7:118784425-118812915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031592
protein coding gene Chr7:116903459-116935288 (-)
WSB/EiJ MGP_WSBEiJ_G0032151
protein coding gene Chr7:131041639-131070159 (-)



Homology
more
  • Human Ortholog
    MVP, major vault protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MVP, major vault protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LRP, VAULT1
  • Links
    NCBI Gene ID: 9961
    neXtProt AC: NX_Q14764
    UniProt: Q14764

  • Chr Location
    16p11.2; chr16:29820394-29848039 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3752
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MVP
  • Gene Tree
    Mvp
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Targeted disruption of this gene does not induce hypersensitivity to various cytostatic agents. Homozygotes are viable, healthy and phenotypically normal and exhibit unimpaired dendritic cell maturation and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 78388 NCBI Gene Model | MGI Sequence Detail 27735 C57BL/6J ±  kb
transcript NM_080638 RefSeq | MGI Sequence Detail 2810 C57BL/6  
polypeptide Q9EQK5 UniProt | EBI | MGI Sequence Detail 861 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 119
    cDNA 119

    Microarray probesets 5
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Diseases 3
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:263550 Wang W, et al., Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. J Neurosci. 2018 Jun 27;38(26):5939-5948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory