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Mvp Gene Detail
Summary
  • Symbol
    Mvp
  • Name
    major vault protein
  • Synonyms
    2310009M24Rik, LRP, VAULT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925638
    NCBI Gene: 78388
  • Gene Overview
    MyGene.info: MVP
Location & Maps
more
  • Sequence Map
    Chr7:126986860-127014621 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27762 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.26 cM, cytoband F4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MVP, major vault protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MVP, major vault protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LRP, VAULT1
  • Links
    NCBI Gene ID: 9961
    neXtProt AC: NX_Q14764

  • Chr Location
    16p11.2; chr16:29820394-29848039 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3752
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MVP
  • Gene Tree
    Mvp
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Mvp
  • Incidental Mutations
Targeted disruption of this gene does not induce hypersensitivity to various cytostatic agents. Homozygotes are viable, healthy and phenotypically normal and exhibit unimpaired dendritic cell maturation and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025144 VEGA Gene Model | MGI Sequence Detail 27762 C57BL/6J ±  kb
transcript OTTMUST00000061863 VEGA | MGI Sequence Detail 2837 Not Applicable  
polypeptide OTTMUSP00000030434 VEGA | MGI Sequence Detail 870 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    188 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    cDNA 118

    Microarray probesets 5
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Diseases 6
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory