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Ccdc88b Gene Detail
Summary
  • Symbol
    Ccdc88b
  • Name
    coiled-coil domain containing 88B
  • Synonyms
    2610041P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925567
    NCBI Gene: 78317
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6844623-6858211 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925567
protein coding gene Chr19:6844623-6858333 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024767
protein coding gene Chr19:3930079-3943667 (-)
A/J MGP_AJ_G0024733
protein coding gene Chr19:3602705-3617792 (-)
AKR/J MGP_AKRJ_G0024706
protein coding gene Chr19:3716023-3729611 (-)
BALB/cJ MGP_BALBcJ_G0024733
protein coding gene Chr19:3714987-3728570 (-)
C3H/HeJ MGP_C3HHeJ_G0024501
protein coding gene Chr19:3844633-3858221 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025179
protein coding gene Chr19:4019650-4033238 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022613
protein coding gene Chr19:3513980-3539061 (-)
CAST/EiJ MGP_CASTEiJ_G0023973
protein coding gene Chr19:3749472-3765518 (-)
CBA/J MGP_CBAJ_G0024473
protein coding gene Chr19:4066758-4080346 (-)
DBA/2J MGP_DBA2J_G0024600
protein coding gene Chr19:3578998-3592586 (-)
FVB/NJ MGP_FVBNJ_G0024566
protein coding gene Chr19:3597739-3611330 (-)
LP/J MGP_LPJ_G0024686
protein coding gene Chr19:3773163-3797145 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024595
protein coding gene Chr19:3974445-3988023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025227
protein coding gene Chr19:3855070-3868658 (-)
PWK/PhJ MGP_PWKPhJ_G0023719
protein coding gene Chr19:3619264-3633260 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023524
protein coding gene Chr19:3672778-3688802 (-)
WSB/EiJ MGP_WSBEiJ_G0024035
protein coding gene Chr19:3748882-3762474 (-)



Homology
more
  • Human Ortholog
    CCDC88B, coiled-coil domain containing 88B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CCDC88B, coiled-coil domain containing 88B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRLZ, CCDC88, gipie, HKRP3
  • Links
    NCBI Gene ID: 283234
    neXtProt AC: NX_A6NC98
    UniProt: A6NC98

  • Chr Location
    11q13.1; chr11:64340203-64357534 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null ENU-induced allele exhibit decreased susceptibility to P. berghei infection with reduced T cell proliferation, decreased cytokine secretion and increased myeloid cell number.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047810 Ensembl Gene Model | MGI Sequence Detail 13589 C57BL/6J ±  kb
transcript ENSMUST00000113440 Ensembl | MGI Sequence Detail 4959 Not Applicable  
polypeptide ENSMUSP00000109067 Ensembl | MGI Sequence Detail 1481 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:250597 Fodil N, et al., CCDC88B is required for pathogenesis of inflammatory bowel disease. Nat Commun. 2017 Oct 13;8(1):932

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory