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Ccdc88b Gene Detail
Summary
  • Symbol
    Ccdc88b
  • Name
    coiled-coil domain containing 88B
  • Synonyms
    2610041P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925567
    NCBI Gene: 78317
Location & Maps
more
  • Sequence Map
    Chr19:6844623-6858211 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13589 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CCDC88B, coiled-coil domain containing 88B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CCDC88B, coiled-coil domain containing 88B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRLZ, CCDC88, gipie, HKRP3
  • Links
    NCBI Gene ID: 283234
    neXtProt AC: NX_A6NC98

  • Chr Location
    11q12.3; chr11:64340197-64357534 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (ENU)
    1
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a null ENU-induced allele exhibit decreased susceptibility to P. berghei infection with reduced T cell proliferation, decreased cytokine secretion and increased myeloid cell number.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047810 Ensembl Gene Model | MGI Sequence Detail 13589 C57BL/6J ±  kb
transcript ENSMUST00000113440 Ensembl | MGI Sequence Detail 4959 Not Applicable  
polypeptide ENSMUSP00000109067 Ensembl | MGI Sequence Detail 1481 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029321 coiled-coil domain-containing protein 88B
  • InterPro Domains
    IPR008636 Hook-related protein family
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 19
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230618 Kennedy JM, et al., CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med. 2014 Dec 15;211(13):2519-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory