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Rrn3 Gene Detail
Summary
  • Symbol
    Rrn3
  • Name
    RRN3 RNA polymerase I transcription factor homolog (yeast)
  • Synonyms
    E130302O19Rik, TIF-1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925255
    NCBI Gene: 106298
  • Gene Overview
    MyGene.info: RRN3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13780708-13814839 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925255
protein coding gene Chr16:13780699-13814841 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022535
protein coding gene Chr16:10778780-10814108 (+)
A/J MGP_AJ_G0022497
protein coding gene Chr16:10188666-10223547 (+)
AKR/J MGP_AKRJ_G0022473
protein coding gene Chr16:10633683-10668879 (+)
BALB/cJ MGP_BALBcJ_G0022501
protein coding gene Chr16:10352248-10387504 (+)
C3H/HeJ MGP_C3HHeJ_G0022268
protein coding gene Chr16:10724326-10760504 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022950
protein coding gene Chr16:10941843-10978517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020470
protein coding gene Chr16:10275599-10313406 (+)
CAST/EiJ MGP_CASTEiJ_G0021795
protein coding gene Chr16:10736474-10778530 (+)
CBA/J MGP_CBAJ_G0022237
protein coding gene Chr16:11464230-11510516 (+)
DBA/2J MGP_DBA2J_G0022368
protein coding gene Chr16:10177689-10211843 (+)
FVB/NJ MGP_FVBNJ_G0022344
protein coding gene Chr16:10164695-10199449 (+)
LP/J MGP_LPJ_G0022436
protein coding gene Chr16:10688067-10722411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022366
protein coding gene Chr16:11092534-11132428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022963
protein coding gene Chr16:10604462-10644056 (+)
PWK/PhJ MGP_PWKPhJ_G0021537
protein coding gene Chr16:10442681-10477947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021365
protein coding gene Chr16:10593296-10631835 (+)
WSB/EiJ MGP_WSBEiJ_G0021843
protein coding gene Chr16:10622912-10659155 (+)



Homology
more
  • Human Ortholog
    RRN3, RRN3 homolog, RNA polymerase I transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RRN3, RRN3 homolog, RNA polymerase I transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A-270G1.2, TIFIA
  • Links
    NCBI Gene ID: 54700
    neXtProt AC: NX_Q9NYV6
    UniProt: Q9NYV6

  • Chr Location
    16p13.11; chr16:15060022-15094335 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 39531
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RRN3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Rrn3 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure to undergo embryonic turning, delayed embryonic development, markedly reduced embryo size, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022682 Ensembl Gene Model | MGI Sequence Detail 34132 C57BL/6J ±  kb
transcript ENSMUST00000023363 Ensembl | MGI Sequence Detail 3582 Not Applicable  
polypeptide ENSMUSP00000023363 Ensembl | MGI Sequence Detail 656 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014308 RNA polymerase I-specific transcription initiation factor RRN3
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR007991 RNA polymerase I specific transcription initiation factor RRN3
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146525, MGI:2146736
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:15147 Schnapp A, et al., Function of the growth-regulated transcription initiation factor TIF-IA in initiation complex formation at the murine ribosomal gene promoter. Mol Cell Biol. 1993 Nov;13(11):6723-32
  • Latest
    J:244454 Herdman C, et al., A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription. PLoS Genet. 2017 Jul;13(7):e1006899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory