Rrn3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rrn3
RRN3 RNA polymerase I transcription factor homolog (yeast)
MGI:1925255

22 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rrn3^tm1.1Igt/Rrn3^tm1.1Igt involves: 129/Sv * C57BL/6	normal cellular phenotype	J:99711
Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0 involves: 129/Sv * C57BL/6	abnormal cell physiology	J:242309
	abnormal mitochondrial morphology	J:168232
	abnormal motor capabilities/coordination/movement	J:168232
	abnormal nucleolus morphology	J:242309
	decreased dopamine level	J:168232
	increased cellular sensitivity to oxidative stress	J:168232
	loss of dopaminergic neurons	J:168232
	neurodegeneration	J:168232
	oxidative stress	J:168232
Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-icre)9190Gsc/0 involves: 129/Sv * C57BL/6 * FVB/N	abnormal gait	J:168232
	abnormal motor capabilities/coordination/movement	J:168232
	abnormal nucleolus morphology	J:168232
	abnormal posture	J:168232
	decreased dopamine level	J:168232
	impaired coordination	J:168232
	jerky movement	J:168232
	loss of dopaminergic neurons	J:168232
	neurodegeneration	J:168232
	slow postnatal weight gain	J:168232
Rrn3^tm1.2Igt/Rrn3^tm1.2Igt involves: 129/Sv * C57BL/6 * SJL	abnormal neural tube morphology	J:99711
	decreased embryo size	J:99711
	embryonic growth retardation	J:99711
	embryonic lethality during organogenesis, complete penetrance	J:99711
	incomplete embryo turning	J:99711
	incomplete somite formation	J:99711
	increased neural tube apoptosis	J:99711

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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