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Dstyk Gene Detail
Summary
  • Symbol
    Dstyk
  • Name
    dual serine/threonine and tyrosine protein kinase
  • Synonyms
    A930019K20Rik, C430014H23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925064
    NCBI Gene: 213452
  • Gene Overview
    MyGene.info: DSTYK
Location & Maps
more
  • Sequence Map
    Chr1:132417555-132466958 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49404 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.24 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DSTYK, dual serine/threonine and tyrosine protein kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DSTYK, dual serine/threonine and tyrosine protein kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5
  • Links
    NCBI Gene ID: 25778
    neXtProt AC: NX_Q6XUX3

  • Chr Location
    1q32.1; chr1:205142503-205211599 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 19711
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DSTYK
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DSTYK associations

Human Disease Mouse Models
       Congenital Anomalies of Kidney and Urinary Tract 1, Susceptibility To; CAKUT1   OMIM: 610805
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Dstyk
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049388 VEGA Gene Model | MGI Sequence Detail 49404 C57BL/6J ±  kb
transcript OTTMUST00000125892 VEGA | MGI Sequence Detail 6282 Not Applicable  
polypeptide OTTMUSP00000068131 VEGA | MGI Sequence Detail 927 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    329 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006714 dual serine/threonine and tyrosine protein kinase
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
less
MGI:1926105
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213892 Sanna-Cherchi S, et al., Mutations in DSTYK and dominant urinary tract malformations. N Engl J Med. 2013 Aug 15;369(7):621-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory