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Esco1 Gene Detail
Summary
  • Symbol
    Esco1
  • Name
    establishment of sister chromatid cohesion N-acetyltransferase 1
  • Synonyms
    A930014I12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925055
    NCBI Gene: 77805
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:10566602-10610352 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 5.21 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925055
protein coding gene Chr18:10566507-10610360 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024148
protein coding gene Chr18:7506696-7552429 (-)
A/J MGP_AJ_G0024110
protein coding gene Chr18:7459455-7504104 (-)
AKR/J MGP_AKRJ_G0024077
protein coding gene Chr18:7645912-7691785 (-)
BALB/cJ MGP_BALBcJ_G0024109
protein coding gene Chr18:7441580-7486055 (-)
C3H/HeJ MGP_C3HHeJ_G0023876
protein coding gene Chr18:7546297-7590147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024554
protein coding gene Chr18:7952602-7999807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021993
protein coding gene Chr18:7117009-7162619 (-)
CAST/EiJ MGP_CASTEiJ_G0023353
protein coding gene Chr18:7440091-7489785 (-)
CBA/J MGP_CBAJ_G0023848
protein coding gene Chr18:8004266-8033885 (-)
DBA/2J MGP_DBA2J_G0023977
protein coding gene Chr18:7320351-7364416 (-)
FVB/NJ MGP_FVBNJ_G0023942
protein coding gene Chr18:7264818-7308841 (-)
LP/J MGP_LPJ_G0024060
protein coding gene Chr18:7634062-7682896 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023971
protein coding gene Chr18:8251505-8300454 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024600
protein coding gene Chr18:7479121-7525952 (-)
PWK/PhJ MGP_PWKPhJ_G0023099
protein coding gene Chr18:7355106-7389220 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022909
protein coding gene Chr18:7746218-7790321 (-)
WSB/EiJ MGP_WSBEiJ_G0023419
protein coding gene Chr18:7454198-7504162 (-)



Homology
more
  • Human Ortholog
    ESCO1, establishment of sister chromatid cohesion N-acetyltransferase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ESCO1, establishment of sister chromatid cohesion N-acetyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A930014I12Rik, CTF, ECO1, EFO1, ESO1
  • Links
    NCBI Gene ID: 114799
    neXtProt AC: NX_Q5FWF5
    UniProt: Q5FWF5

  • Chr Location
    18q11.2; chr18:21529281-21601015 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024293 Ensembl Gene Model | MGI Sequence Detail 43751 C57BL/6J ±  kb
    transcript ENSMUST00000025142 Ensembl | MGI Sequence Detail 4433 Not Applicable  
    polypeptide ENSMUSP00000025142 Ensembl | MGI Sequence Detail 843 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory