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Adamtsl2
Gene Detail
Symbol

Name
ID
Adamtsl2
ADAMTS-like 2
MGI:1925044
Synonyms
A930008K15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.22 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:27079379-27108981 bp, + strand
From VEGA annotation of GRCm38

  29603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8798  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTSL2
Gene Tree: Adamtsl2

Human
homologs
ADAMTSL2, ADAMTS-like 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9719
neXtProt AC: NX_Q86TH1

Human Synonyms: GPHYSD1

Human Chr (Location): 9q34.2; chr9:133532164-133575519 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADAMTSL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Adamtsl2 interacts with 90 markers (Mir23a, Mir23b, Mir27a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (169)    Tissues (55)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 141
Northern blot 11
RT-PCR 1
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011845 (Evidence)
Ensembl Gene Model ENSMUSG00000036040 (Evidence)
Entrez Gene 77794 (Evidence)
UniGene 330088
DFCI TC1752336, TC1588404, TC1586668
DoTS DT.40147919, DT.103560057, DT.40148123
NIA Mouse Gene Index U001530
Consensus CDS Project CCDS15824.1
International Mouse Phenotyping Consortium Status Adamtsl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011845 VEGA Gene Model | MGI Sequence Detail 29603 C57BL/6J ±  kb
transcript OTTMUST00000027839 VEGA | MGI Sequence Detail 3612 Not Applicable 
polypeptide OTTMUSP00000012646 VEGA | MGI Sequence Detail 957 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(372 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003739 ADAMTS-like protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:221347 Hubmacher D, et al., Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia - a novel mouse model providing insights into geleophysic dysplasia. Dis Model Mech. 2015 May 1;8(5):487-99
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory