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Kcnq5 Gene Detail
Summary
  • Symbol
    Kcnq5
  • Name
    potassium voltage-gated channel, subfamily Q, member 5
  • Synonyms
    9230107O05Rik, D1Mgi1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924937
    NCBI Gene: 226922
  • Gene Overview
    MyGene.info: KCNQ5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:21398403-21961942 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 6.67 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924937
protein coding gene Chr1:21398399-21962650 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015881
protein coding gene Chr1:19082445-19704017 (-)
A/J MGP_AJ_G0015862
protein coding gene Chr1:18831030-19406639 (-)
AKR/J MGP_AKRJ_G0015819
protein coding gene Chr1:18916858-19515798 (-)
BALB/cJ MGP_BALBcJ_G0015818
protein coding gene Chr1:18530698-19125558 (-)
C3H/HeJ MGP_C3HHeJ_G0015652
protein coding gene Chr1:18934375-19540607 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016272
protein coding gene Chr1:19990969-20618514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013991
protein coding gene Chr1:16957340-17555517 (-)
CAST/EiJ MGP_CASTEiJ_G0015231
protein coding gene Chr1:19011677-19635178 (-)
CBA/J MGP_CBAJ_G0015624
protein coding gene Chr1:20445796-21125440 (-)
DBA/2J MGP_DBA2J_G0015723
protein coding gene Chr1:18340821-18917693 (-)
FVB/NJ MGP_FVBNJ_G0015727
protein coding gene Chr1:18110442-18682120 (-)
LP/J MGP_LPJ_G0015795
protein coding gene Chr1:19336422-19923091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015747
protein coding gene Chr1:21355170-22076964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016319
protein coding gene Chr1:18857414-19456693 (-)
PWK/PhJ MGP_PWKPhJ_G0015014
protein coding gene Chr1:18105492-18682821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014795
protein coding gene Chr1:18946259-19551020 (-)
WSB/EiJ MGP_WSBEiJ_G0015294
protein coding gene Chr1:18816394-19428948 (-)



Homology
more
  • Human Ortholog
    KCNQ5, potassium voltage-gated channel subfamily Q member 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KCNQ5, potassium voltage-gated channel subfamily Q member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Kv7.5, MRD46
  • Links
    NCBI Gene ID: 56479
    neXtProt AC: NX_Q9NR82
    UniProt: Q9NR82

  • Chr Location
    6q13; chr6:72621843-73198851 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KCNQ5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a dominant negative knock-in mutation in this gene exhibit partial prenatal lethality and abnormal afterhyperpolarization in the in the CA3 area of hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028033 Ensembl Gene Model | MGI Sequence Detail 563540 C57BL/6J ±  kb
transcript ENSMUST00000115300 Ensembl | MGI Sequence Detail 6975 Not Applicable  
polypeptide ENSMUSP00000110955 Ensembl | MGI Sequence Detail 952 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR003937 Potassium channel, voltage dependent, KCNQ
    IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
    IPR028325 Voltage-gated potassium channel
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138116
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory