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Kcnq5
Gene Detail
Symbol

Name
ID
Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
MGI:1924937
Synonyms
9230107O05Rik, D1Mgi1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
6.67 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:21398403-21961942 bp, - strand
From VEGA annotation of GRCm38

  563540 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:28270  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: KCNQ5
Protein SuperFamily: potassium voltage-gated channel, subfamily KQT
Gene Tree: Kcnq5

Human
homologs
KCNQ5, potassium channel, voltage gated KQT-like subfamily Q, member 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 56479
neXtProt AC: NX_Q9NR82

Human Synonyms: Kv7.5

Human Chr (Location): 6q14; chr6:72621280-73198851 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a dominant negative knock-in mutation in this gene exhibit partial prenatal lethality and abnormal afterhyperpolarization in the in the CA3 area of hippocampus.
 
Interactions
Kcnq5 interacts with 402 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnq2 ; ZFIN kcnq5a, kcnq5b    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000019675 (Evidence)
Ensembl Gene Model ENSMUSG00000028033 (Evidence)
Entrez Gene 226922 (Evidence)
DFCI TC1597588, TC1634911, TC1637887, TC1645078, TC1734972
DoTS DT.101718865, DT.484584, DT.60103390, DT.97357763
NIA Mouse Gene Index U021168
Consensus CDS Project CCDS35525.1, CCDS48230.1, CCDS78554.1
International Mouse Phenotyping Consortium Status Kcnq5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019675 VEGA Gene Model | MGI Sequence Detail 563540 C57BL/6J ±  kb
transcript OTTMUST00000047088 VEGA | MGI Sequence Detail 6975 Not Applicable 
polypeptide OTTMUSP00000021274 VEGA | MGI Sequence Detail 952 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(5487 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5493)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR003091 Potassium channel
InterPro IPR003937 Potassium channel, voltage dependent, KCNQ
InterPro IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
InterPro IPR028325 Voltage-gated potassium channel
Protein Ontology PR:000000732 voltage-gated potassium channel subunit KCNQ5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:221364 Fidzinski P, et al., KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations. Nat Commun. 2015;6:6254
All references(37)
Other
accession IDs
MGI:2138116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory