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Pramel13 Gene Detail
Summary
  • Symbol
    Pramel13
  • Name
    PRAME like 13
  • Synonyms
    4930569K13Rik, Pramef12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924882
    NCBI Gene: 77632
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:144118244-144135034 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 77.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924882
 protein coding gene Chr4:144118244-144135037 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029090
 protein coding gene Chr4:147751193-147769525 (-)
A/J MGP_AJ_G0029057
 protein coding gene Chr4:141475155-141491913 (-)
AKR/J MGP_AKRJ_G0029005
 protein coding gene Chr4:145455344-145472121 (-)
BALB/cJ MGP_BALBcJ_G0029072
 protein coding gene Chr4:142128277-142145032 (-)
C3H/HeJ MGP_C3HHeJ_G0028791
 protein coding gene Chr4:145902432-145921644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029517
 protein coding gene Chr4:152753383-152778787 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026769
 protein coding gene Chr4:134171273-134187622 (-)
CAST/EiJ MGP_CASTEiJ_G0028207
 protein coding gene Chr4:143977143-143996510 (-)
CBA/J MGP_CBAJ_G0028755
 protein coding gene Chr4:157512249-157561461 (-)
DBA/2J MGP_DBA2J_G0028903
 protein coding gene Chr4:141703703-141720691 (-)
FVB/NJ MGP_FVBNJ_G0028865
 protein coding gene Chr4:140837021-140853766 (-)
LP/J MGP_LPJ_G0028994
 protein coding gene Chr4:147812973-147830685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028895
 protein coding gene Chr4:161091330-161110385 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029554
 protein coding gene Chr4:145918417-145938063 (-)
PWK/PhJ MGP_PWKPhJ_G0027927
 protein coding gene Chr4:138183380-138200910 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027761
 protein coding gene Chr4:141197921-141214436 (-)
WSB/EiJ MGP_WSBEiJ_G0028286
 protein coding gene Chr4:146182840-146200140 (-)



Homology
more
  • Human Ortholog
    PRAME, PRAME nuclear receptor transcriptional regulator
  • Vertebrate Orthologs
    23
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRAME, PRAME nuclear receptor transcriptional regulator
  • Synonyms
    CT130, MAPE, OIP4, OIP-4
  • Links
    NCBI Gene ID: 23532
    neXtProt AC: NX_P78395
    UniProt: P78395

  • Chr Location
    22q11.22; chr22:22547701-22559361 (-)  GRCh38
  • Human Ortholog
    PRAMEF1, PRAME family member 1
  • Links
    NCBI Gene ID: 65121
    neXtProt AC: NX_O95521
    UniProt: O95521

  • Chr Location
    1p36.21; chr1:12791397-12796628 (+)  GRCh38
  • Human Ortholog
    PRAMEF10, PRAME family member 10
  • Links
    NCBI Gene ID: 343071
    neXtProt AC: NX_O60809
    UniProt: O60809

  • Chr Location
    1p36.21; chr1:12892896-12898270 (-)  GRCh38
  • Human Ortholog
    PRAMEF11, PRAME family member 11
  • Links
    NCBI Gene ID: 440560
    neXtProt AC: NX_O60813
    UniProt: O60813

  • Chr Location
    1p36.21; chr1:12824605-12831410 (-)  GRCh38
  • Human Ortholog
    PRAMEF12, PRAME family member 12
  • Links
    NCBI Gene ID: 390999
    neXtProt AC: NX_O95522
    UniProt: O95522

  • Chr Location
    1p36.21; chr1:12773738-12777906 (+)  GRCh38
  • Human Ortholog
    PRAMEF13, PRAME family member 13
  • Links
    NCBI Gene ID: 400736
    neXtProt AC: NX_Q5VWM6
    UniProt: Q5VWM6

  • Chr Location
    1p36.21; chr1:13196188-13201409 (-)  GRCh38
  • Human Ortholog
    PRAMEF17, PRAME family member 17
  • Links
    NCBI Gene ID: 391004
    neXtProt AC: NX_Q5VTA0
    UniProt: Q5VTA0

  • Chr Location
    1p36.21; chr1:13389632-13392629 (+)  GRCh38
  • Human Ortholog
    PRAMEF18, PRAME family member 18
  • Links
    NCBI Gene ID: 391003
    neXtProt AC: NX_Q5VWM3
    UniProt: Q5VWM3

  • Chr Location
    1p36.21; chr1:13222695-13226154 (-)  GRCh38
  • Human Ortholog
    PRAMEF19, PRAME family member 19
  • Links
    NCBI Gene ID: 645414
    neXtProt AC: NX_Q5SWL8
    UniProt: Q5SWL8

  • Chr Location
    1p36.21; chr1:13368431-13371947 (-)  GRCh38
  • Human Ortholog
    PRAMEF20, PRAME family member 20
  • Synonyms
    PRAMEF21
  • Links
    NCBI Gene ID: 645425
    neXtProt AC: NX_Q5VT98
    UniProt: Q5VT98

  • Chr Location
    1p36.21; chr1:13410450-13421328 (+)  GRCh38
  • Human Ortholog
    PRAMEF22, PRAME family member 22
  • Synonyms
    PRAMEF3L
  • Links
    NCBI Gene ID: 653606
    neXtProt AC: NX_A3QJZ6
    UniProt: A3QJZ6

  • Chr Location
    1p36.21; chr1:13005048-13005624 (+)  GRCh38
  • Human Ortholog
    PRAMEF25, PRAME family member 25
  • Links
    NCBI Gene ID: 441873
    neXtProt AC: NX_A6NGN4
    UniProt: A6NGN4

  • Chr Location
    1p36.21; chr1:13068677-13077884 (+)  GRCh38
  • Human Ortholog
    PRAMEF26, PRAME family member 26
  • Synonyms
    PRAMEF25
  • Links
    NCBI Gene ID: 645359
    neXtProt AC: NX_A6NGN4
    UniProt: H0Y7S4

  • Chr Location
    1p36.21
  • Human Ortholog
    PRAMEF27, PRAME family member 27
  • Links
    NCBI Gene ID: 101929983
    neXtProt AC: NX_A3QJZ7
    UniProt: A3QJZ7

  • Chr Location
    chr1:13049476-13056575 (-)  GRCh38
  • Human Ortholog
    PRAMEF33, PRAME family member 33
  • Synonyms
    PRAMEF33P
  • Links
    NCBI Gene ID: 645382
    neXtProt AC: NX_A0A0G2JMD5
    UniProt: A0A0G2JMD5

  • Chr Location
    1p36.21; chr1:13303539-13308907 (+)  GRCh38
  • Human Ortholog
    PRAMEF4, PRAME family member 4
  • Links
    NCBI Gene ID: 400735
    neXtProt AC: NX_O60810
    UniProt: O60810

  • Chr Location
    1p36.21; chr1:12879212-12886201 (-)  GRCh38
  • Human Ortholog
    PRAMEF5, PRAME family member 5
  • Synonyms
    PRAMEF23, PRAMEF5L
  • Links
    NCBI Gene ID: 343068
    neXtProt AC: NX_Q5TYX0
    UniProt: Q5TYX0

  • Chr Location
    1p36.21; chr1:13254198-13263435 (+)  GRCh38
  • Human Ortholog
    PRAMEF6, PRAME family member 6
  • Links
    NCBI Gene ID: 440561
    neXtProt AC: NX_Q5VXH4
    UniProt: Q5VXH4

  • Chr Location
    1p36.21; chr1:12938472-12947580 (-)  GRCh38
  • Human Ortholog
    PRAMEF7, PRAME family member 7
  • Links
    NCBI Gene ID: 441871
    neXtProt AC: NX_Q5VXH5
    UniProt: Q5VXH5

  • Chr Location
    1p36.21; chr1:12916610-12920751 (+)  GRCh38
  • Human Ortholog
    PRAMEF8, PRAME family member 8
  • Synonyms
    PRAMEF24
  • Links
    NCBI Gene ID: 391002
    neXtProt AC: NX_Q5VWM4
    UniProt: Q5VWM4

  • Chr Location
    1p36.21; chr1:13281304-13285137 (-)  GRCh38
  • Human Ortholog
    PRAMEF9, PRAME family member 9
  • Links
    NCBI Gene ID: 343070
    UniProt: P0DUQ2

  • Chr Location
    1p36.21; chr1:13171848-13179459 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRAME associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility, small testes, and azoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    61
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028591 Ensembl Gene Model | MGI Sequence Detail 16791 C57BL/6J ±  kb
    transcript ENSMUST00000123854 Ensembl | MGI Sequence Detail 1596 Not Applicable  
    polypeptide ENSMUSP00000119614 Ensembl | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR032675 Leucine-rich repeat domain superfamily
      IPR026271 PRAME
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 61
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140472, MGI:2140703
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:338693 Li N, et al., MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice. Biochem Biophys Res Commun. 2023 Jul 10;675:46-53
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory