Automated description from the Alliance of Genome Resources (Release 5.4.0)
Predicted to enable nuclear retinoic acid receptor binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to several human genes including PRAMEF12 (PRAME family member 12).