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Apex2 Gene Detail
Summary
  • Symbol
    Apex2
  • Name
    apurinic/apyrimidinic endonuclease 2
  • Synonyms
    Ape2, C430040P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924872
    NCBI Gene: 77622
Location & Maps
more
  • Sequence Map
    ChrX:150519519-150589868 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70350 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    APEX2, apurinic/apyrimidinic endodeoxyribonuclease 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APEX2, apurinic/apyrimidinic endodeoxyribonuclease 2
    Orthology source: HomoloGene
  • Synonyms
    APE2, APEXL2, XTH2, ZGRF2
  • Links
    NCBI Gene ID: 27301
    neXtProt AC: NX_Q9UBZ4

  • Chr Location
    Xp11.21; chrX:55000323-55007873 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5344
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: APEX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Hemizygous null male mice display mild growth retardation, thymic atrophy, reduced white blood cell counts, and a slight decrease in red blood cell count.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019152 VEGA Gene Model | MGI Sequence Detail 70350 C57BL/6J ±  kb
transcript OTTMUST00000045906 VEGA | MGI Sequence Detail 1852 Not Applicable  
polypeptide OTTMUSP00000020684 VEGA | MGI Sequence Detail 523 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    350 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:212093 Stavnezer J, et al., Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9217-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory