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Mboat7 Gene Detail
Summary
  • Symbol
    Mboat7
  • Name
    membrane bound O-acyltransferase domain containing 7
  • Synonyms
    5730589L02Rik, Leng4, Lpiat1, mBB1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924832
    NCBI Gene: 77582
  • Gene Overview
    MyGene.info: MBOAT7
Location & Maps
more
Homology
more
  • Human Ortholog
    MBOAT7, membrane bound O-acyltransferase domain containing 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MBOAT7, membrane bound O-acyltransferase domain containing 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BB1, hMBOA-7, LENG4, LPIAT, LRC4, MBOA7, OACT7
  • Links
    NCBI Gene ID: 79143
    neXtProt AC: NX_Q96N66

  • Chr Location
    19q13.4; chr19:54173412-54189882 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a targeted mutation exhibit hydrocephaly and most die between 1-3 months of age. Mice homozygous for a knock-out allele exhibit partial lethality with decreased body size, decreased forebrain size, delayed neuronal migrationand reduced neurite outgrowth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023042 VEGA Gene Model | MGI Sequence Detail 15735 C57BL/6J ±  kb
transcript OTTMUST00000055526 VEGA | MGI Sequence Detail 2878 Not Applicable  
polypeptide OTTMUSP00000026598 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    138 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010227 lysophospholipid acyltransferase 7
  • EC
  • InterPro Domains
    IPR004299 Membrane bound O-acyl transferase, MBOAT
Molecular
Reagents
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  • All nucleic 121
    cDNA 121

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:215301 Hirata Y, et al., Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein. Genes Cells. 2013 May;18(5):397-409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory