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Mboat7 Gene Detail
Summary
  • Symbol
    Mboat7
  • Name
    membrane bound O-acyltransferase domain containing 7
  • Synonyms
    5730589L02Rik, Leng4, Lpiat1, mBB1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924832
    NCBI Gene: 77582
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3680788-3696188 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.12 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    466 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924832
 protein coding gene Chr7:3680788-3696522 (-)
129S1/SvImJ ENSMUSGG00200054859
 protein coding gene Chr7:606783-606949 (-)
129S1/SvImJ ENSMUSG00200040783
 protein coding gene Chr7:606989-613362 (-)
A/J ENSMUSGG00195055385
 protein coding gene Chr7:524793-524959 (-)
A/J ENSMUSG00195048570
 protein coding gene Chr7:524999-531367 (-)
AKR/J ENSMUSGG00220054875
 protein coding gene Chr7:3501196-3501362 (+)
AKR/J ENSMUSG00220023770
 protein coding gene Chr7:3494791-3501156 (+)
BALB/cJ ENSMUSGG00180055079
 protein coding gene Chr7:525415-525581 (-)
BALB/cJ ENSMUSG00180045833
 protein coding gene Chr7:525621-531996 (-)
C3H/HeJ ENSMUSG00175045219
 protein coding gene Chr7:518011-524382 (-)
C3H/HeJ ENSMUSGG00175054627
 protein coding gene Chr7:517805-517971 (-)
C57BL/6NJ ENSMUSG00215037565
 protein coding gene Chr7:510934-517077 (-)
C57BL/6NJ ENSMUSGG00215055248
 protein coding gene Chr7:510728-510894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029098
 protein coding gene Chr7:450487-465906 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054986
 protein coding gene Chr7:517741-517907 (-)
CBA/J ENSMUSG00210038250
 protein coding gene Chr7:517947-524319 (-)
DBA/2J ENSMUSGG00185057876
 protein coding gene Chr7:703206-703372 (-)
DBA/2J ENSMUSG00185040610
 protein coding gene Chr7:703412-709781 (-)
FVB/NJ ENSMUSG00205035643
 protein coding gene Chr7:521576-527948 (-)
FVB/NJ ENSMUSGG00205054146
 protein coding gene Chr7:521370-521536 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230036643
 protein coding gene Chr7:3724980-3731351 (-)
LP/J ENSMUSGG00230055564
 protein coding gene Chr7:3724774-3724940 (-)
NOD/ShiLtJ ENSMUSGG00190054978
 protein coding gene Chr7:524681-524847 (-)
NOD/ShiLtJ ENSMUSG00190045524
 protein coding gene Chr7:524887-531252 (-)
NZO/HlLtJ ENSMUSG00225019860
 protein coding gene Chr7:1531144-1537287 (-)
NZO/HlLtJ ENSMUSGG00225055246
 protein coding gene Chr7:1530938-1531104 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010047535
 protein coding gene Chr7:712324-728098 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MBOAT7, membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBOAT7, membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
  • Synonyms
    BB1, hMBOA-7, LENG4, LPIAT, LPIAT1, LPLAT, LPLAT11, LRC4, MBOA7, MRT57, OACT7
  • Links
    NCBI Gene ID: 79143
    UniProt: Q96N66

  • Chr Location
    19q13.42; chr19:54173412-54189882 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mboat7 mouse models; 1 with human MBOAT7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit hydrocephaly and most die between 1-3 months of age. Mice homozygous for a knock-out allele exhibit partial lethality with decreased body size, decreased forebrain size, delayed neuronal migrationand reduced neurite outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    134
  • cDNA Data
    123
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77582 NCBI Gene Model | MGI Sequence Detail 15401 C57BL/6J ±  kb
    transcript NM_029934 RefSeq | MGI Sequence Detail 2341 C57BL/6  
    polypeptide Q8CHK3 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010227 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
      (term hierarchy)
    • EC
      2.3.1.-
    • InterPro Domains
      IPR049941 Lysophospholipid acyltransferase 7/Porcupine-like
      IPR004299 Membrane bound O-acyl transferase, MBOAT
    • GlyGen
      Q8CHK3 3 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 123
      cDNA 123
      Antibodies 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:377402 Ishino Y, et al., LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex. iScience. 2026 Jan 16;29(1):114248
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory