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Mboat7
Gene Detail
Symbol

Name
ID
Mboat7
membrane bound O-acyltransferase domain containing 7
MGI:1924832
Synonyms
5730589L02Rik, Leng4, Lpiat1, mBB1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.12 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:3677790-3693523 bp, - strand
From VEGA annotation of GRCm38

  15734 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11510  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MBOAT7
Gene Tree: Mboat7

Human
homologs
MBOAT7, membrane bound O-acyltransferase domain containing 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 79143
neXtProt AC: NX_Q96N66

Human Synonyms: BB1, hMBOA-7, LENG4, LPIAT, LRC4, MBOA7, OACT7

Human Chr (Location): 19q13.4; chr19:54173412-54189882 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit hydrocephaly and most die between 1-3 months of age. Mice homozygous for a knock-out allele exhibit partial lethality with decreased body size, decreased forebrain size, delayed neuronal migrationand reduced neurite outgrowth.
 
Phenotype Images(1)
Interactions
Mboat7 interacts with 237 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (117)    Tissues (97)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(121)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mboat7 ; ZFIN mboat7    NEW 
Molecular
reagents
All nucleic(121) cDNA(121)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023042 (Evidence)
Ensembl Gene Model ENSMUSG00000035596 (Evidence)
Entrez Gene 77582 (Evidence)
UniGene 397541
DFCI TC1752152, TC1605422, TC1615555, TC1601165, TC1572281
DoTS DT.94259919, DT.101719249, DT.91426864, DT.101390645, DT.490593, DT.101139328, DT.101157164
NIA Mouse Gene Index U028073
EC 2.3.1.-
Consensus CDS Project CCDS20724.1
International Mouse Phenotyping Consortium Status Mboat7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023042 VEGA Gene Model | MGI Sequence Detail 15734 C57BL/6J ±  kb
transcript OTTMUST00000055526 VEGA | MGI Sequence Detail 2877 Not Applicable 
polypeptide OTTMUSP00000026598 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
Protein Ontology PR:000010227 lysophospholipid acyltransferase 7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199847 Anderson KE, et al., Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse. PLoS One. 2013;8(3):e58425
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory