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Coq6 Gene Detail
Summary
  • Symbol
    Coq6
  • Name
    coenzyme Q6 monooxygenase
  • Synonyms
    5930427M12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924408
    NCBI Gene: 217707
  • Gene Overview
    MyGene.info: COQ6
Location & Maps
more
  • Sequence Map
    Chr12:84361657-84373796 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12140 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.18 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    COQ6, coenzyme Q6, monooxygenase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COQ6, coenzyme Q6, monooxygenase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI10, CGI-10, COQ10D6
  • Links
    NCBI Gene ID: 51004
    neXtProt AC: NX_Q9Y2Z9

  • Chr Location
    14q24.3; chr14:73949934-73963112 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6039
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: COQ6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human COQ6 associations

Human Disease Mouse Models
       Coenzyme Q10 Deficiency, Primary, 6; COQ10D6   OMIM: 614650
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Coq6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023378 VEGA Gene Model | MGI Sequence Detail 12140 C57BL/6J ±  kb
transcript OTTMUST00000056720 VEGA | MGI Sequence Detail 1776 Not Applicable  
polypeptide OTTMUSP00000027290 VEGA | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005755 ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
  • EC
  • InterPro Domains
    IPR002938 FAD-binding domain
    IPR023753 FAD/NAD(P)-binding domain
    IPR010971 Ubiquinone biosynthesis hydroxylase UbiH/COQ6
    IPR018168 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site
    IPR000689 Ubiquinone biosynthesis monooxygenase COQ6
Molecular
Reagents
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  • All nucleic 54
    cDNA 54

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:172853 Kohr MJ, et al., Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory