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Trip11 Gene Detail
Summary
  • Symbol
    Trip11
  • Name
    thyroid hormone receptor interactor 11
  • Synonyms
    2610511G22Rik, 3110031G15Rik, 6030460N08Rik, GMAP-210, TRIP230
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924393
    NCBI Gene: 109181
  • Gene Overview
    MyGene.info: TRIP11
Location & Maps
more
  • Sequence Map
    Chr12:101834043-101913267 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79225 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.30 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRIP11, thyroid hormone receptor interactor 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIP11, thyroid hormone receptor interactor 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACG1A, CEV14, GMAP210, GMAP-210, TRIP-11, TRIP230
  • Links
    NCBI Gene ID: 9321
    neXtProt AC: NX_Q15643

  • Chr Location
    14q32.12; chr14:91965991-92040140 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Trip11 mouse models; 1 with human TRIP11 associations

Human Disease Mouse Models
       Achondrogenesis, Type IA; ACG1A   OMIM: 200600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Targeted
    2
  • Genomic Mutations
    1 involving Trip11
  • Incidental Mutations
Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039943 VEGA Gene Model | MGI Sequence Detail 79225 C57BL/6J ±  kb
transcript OTTMUST00000103784 VEGA | MGI Sequence Detail 9873 Not Applicable  
polypeptide OTTMUSP00000058012 VEGA | MGI Sequence Detail 1976 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    487 from dbSNP Build 142
Protein
Information
less
  • UniProt
    11 Sequences
  • InterPro Domains
    IPR000237 GRIP domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1917181, MGI:1920385, MGI:2144830
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:217667 May-Simera HL, et al., Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. Development. 2015 Feb 1;142(3):555-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory