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Trip11 Gene Detail
Summary
  • Symbol
    Trip11
  • Name
    thyroid hormone receptor interactor 11
  • Synonyms
    2610511G22Rik, 3110031G15Rik, 6030460N08Rik, GMAP-210, TRIP230
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924393
    NCBI Gene: 109181
  • Gene Overview
    MyGene.info: TRIP11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:101834043-101913171 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.30 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924393
protein coding gene Chr12:101834043-101913267 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020026
protein coding gene Chr12:103432247-103517051 (-)
A/J MGP_AJ_G0019982
protein coding gene Chr12:99462204-99542845 (-)
AKR/J MGP_AKRJ_G0019958
protein coding gene Chr12:102296650-102378005 (-)
BALB/cJ MGP_BALBcJ_G0019968
protein coding gene Chr12:99810313-99885694 (-)
C3H/HeJ MGP_C3HHeJ_G0019770
protein coding gene Chr12:102741933-102828086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020417
protein coding gene Chr12:106672517-106761708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018030
protein coding gene Chr12:96499181-96571580 (-)
CAST/EiJ MGP_CASTEiJ_G0019316
protein coding gene Chr12:97566219-97647295 (-)
CBA/J MGP_CBAJ_G0019742
protein coding gene Chr12:110607272-110696315 (-)
DBA/2J MGP_DBA2J_G0019853
protein coding gene Chr12:98987414-99068370 (-)
FVB/NJ MGP_FVBNJ_G0019842
protein coding gene Chr12:97704896-97785168 (-)
LP/J MGP_LPJ_G0019929
protein coding gene Chr12:103294820-103372989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019882
protein coding gene Chr12:114111130-114193064 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020446
protein coding gene Chr12:101801600-101880299 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018875
protein coding gene Chr12:95976598-96060761 (-)
WSB/EiJ MGP_WSBEiJ_G0019370
protein coding gene Chr12:102680588-102762298 (-)



Homology
more
  • Human Ortholog
    TRIP11, thyroid hormone receptor interactor 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIP11, thyroid hormone receptor interactor 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACG1A, CEV14, GMAP210, GMAP-210, TRIP-11, TRIP230
  • Links
    NCBI Gene ID: 9321
    neXtProt AC: NX_Q15643
    UniProt: Q15643

  • Chr Location
    14q32.12; chr14:91965991-92040140 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Trip11 mouse models; 1 with human TRIP11 associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 4 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109181 NCBI Gene Model | MGI Sequence Detail 79129 C57BL/6J ±  kb
    transcript NM_028446 RefSeq | MGI Sequence Detail 6448 C57BL/6  
    polypeptide NP_082722 RefSeq | MGI Sequence Detail 1976 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR000237 GRIP domain
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917181, MGI:1920385, MGI:2144830
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:253969 Bird IM, et al., The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 Jan 8;145(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory