Trip11^tm1.1Psmi
Targeted Allele Detail

Summary

• Symbol: Trip11^tm1.1Psmi
• Name: thyroid hormone receptor interactor 11; targeted mutation 1.1, Patrick Smits
• MGI ID: MGI:6154012
• Synonyms: Trip11^cko
• Gene: Trip11 Location: Chr12:101800304-101879463 bp, - strand Genetic Position: Chr12, 51.3 cM, cytoband F1
• Alliance: Trip11^tm1.1Psmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 671 bp upstream of exon 1 (which contains the ATG) and an FRT site-flanked neomycin selection cassette immediately followed by a loxP site was placed 1506 bp downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:253969)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trip11 Mutation: 99 strains or lines available

References

• Original: J:253969 Bird IM, et al., The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects. Development. 2018 Jan 8;145(1):dev156588
• All: 3 reference(s)