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Il33 Gene Detail
Summary
  • Symbol
    Il33
  • Name
    interleukin 33
  • Synonyms
    9230117N10Rik, Il1f11, Il-33, NF-HEV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924375
    NCBI Gene: 77125
  • Gene Overview
    MyGene.info: IL33
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:29925114-29960718 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35605 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 24.56 cM, cytoband C2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IL33, interleukin 33
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IL33, interleukin 33
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C9orf26, DVS27, IL1F11, NFEHEV, NF-HEV
  • Links
    NCBI Gene ID: 90865
    neXtProt AC: NX_O95760
    UniProt: O95760

  • Chr Location
    9p24.1; chr9:6214591-6257983 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations lead to altered Type 2 immunity and increased susceptibility to parasite infection. Homozygotes for a null allele show accelerated ovarian functional decline and early reproductive aging due to impaired migration of ovarian macrophages and failed disposal of atretic follicles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028342 VEGA Gene Model | MGI Sequence Detail 35605 C57BL/6J ±  kb
    transcript OTTMUST00000070253 VEGA | MGI Sequence Detail 2544 Not Applicable  
    polypeptide OTTMUSP00000035770 VEGA | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      217 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 4
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 76
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:260256 Zoltowska Nilsson AM, et al., Mast cell-dependent IL-33/ST2 signaling is protective against the development of airway hyperresponsiveness in a house dust mite mouse model of asthma. Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L484-L492

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory