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Il33
Gene Detail
Symbol

Name
ID
Il33
interleukin 33
MGI:1924375
Synonyms
9230117N10Rik, Il1f11, Il-33, NF-HEV
Feature Type
protein coding gene
Genetic Map
Chromosome 19
24.56 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:29925114-29960718 bp, + strand
From VEGA annotation of GRCm38

  35605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: IL33
Protein SuperFamily: interleukin-33
Gene Tree: Il33

Human
homologs
IL33, interleukin 33
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 90865
neXtProt AC: NX_O95760

Human Synonyms: C9orf26, DVS27, IL1F11, NFEHEV, NF-HEV

Human Chr (Location): 9p24.1; chr9:6215149-6257983 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased inflammatory reaction to ovalbumin, papain, and LPS endotoxin shock but increased susceptibility to DSS-induced colitis. Mice homozygous for another knock-out allele exhibit impaired Th2 response to S venezuelensis.
 
Phenotype Images(1)
Interactions
Il33 interacts with 259 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process defense response to virus, extrinsic apoptotic signaling pathway, ...
Component chromosome, cytoplasmic vesicle, ...
Function cytokine activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (82)    Tissues (9)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028342 (Evidence)
Ensembl Gene Model ENSMUSG00000024810 (Evidence)
Entrez Gene 77125 (Evidence)
UniGene 182359
DFCI TC1577383
DoTS DT.101185966, DT.528658
NIA Mouse Gene Index U019359
Consensus CDS Project CCDS29740.1
International Mouse Phenotyping Consortium Status Il33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028342 VEGA Gene Model | MGI Sequence Detail 35605 C57BL/6J ±  kb
transcript OTTMUST00000070252 VEGA | MGI Sequence Detail 2537 Not Applicable 
polypeptide OTTMUSP00000035769 VEGA | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026145 Interleukin-33
Protein Ontology PR:000001389 interleukin-33
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219889 Gadani SP, et al., The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron. 2015 Feb 18;85(4):703-9
All references(100)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory