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Atg16l1
Gene Detail
Symbol

Name
ID
Atg16l1
autophagy related 16-like 1 (S. cerevisiae)
MGI:1924290
Synonyms
1500009K01Rik, APG16L, WDR30
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:87755870-87792428 bp, + strand
From VEGA annotation of GRCm38

  36559 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATG16L1
Gene Tree: Atg16l1

Human
homologs
ATG16L1, autophagy related 16-like 1 (S. cerevisiae)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55054
neXtProt AC: NX_Q676U5

Human Synonyms: APG16L, ATG16A, ATG16L, IBD10, WDR30

Human Chr (Location): 2q37.1; chr2:233251571-233295674 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ATG16L1

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null homozygotes have a cellular defect in autophagy that results in lethality during the neonatal starvation period. Mice homozygous for hypomorphic alleles have Paneth cells with aberrant, disorganized granules similar to those found in patients with Crohn's disease.
 
Human Diseases Modeled in Mice Using Atg16l1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Atg16l1 interacts with 242 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process autophagosome assembly, autophagy, ...
Component autophagosome, autophagosome membrane, ...
Function identical protein binding, protein binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (42)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atg16l1 ; ZFIN atg16l1    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016467 (Evidence)
Ensembl Gene Model ENSMUSG00000026289 (Evidence)
Entrez Gene 77040 (Evidence)
DFCI TC1606623, TC1602649, TC1602002, TC1595114, TC1592231, TC1575367, TC1646272
DoTS DT.55141134, DT.110932139, DT.101394504, DT.101720679, DT.101707747, DT.94281541, DT.91342401, DT.87042734, DT.97393709, DT.99860478
NIA Mouse Gene Index U000563
Consensus CDS Project CCDS15136.1, CCDS56637.1, CCDS56638.1
International Mouse Phenotyping Consortium Status Atg16l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016467 VEGA Gene Model | MGI Sequence Detail 36559 C57BL/6J ±  kb
transcript OTTMUST00000039678 VEGA | MGI Sequence Detail 3102 Not Applicable 
polypeptide OTTMUSP00000017709 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(9) UniProt(5)
Polymorphisms
SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013923 Autophagy-related protein 16
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004409 autophagy-related protein 16-1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213671 Uemura T, et al., A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane. Mol Cell Biol. 2014 May;34(9):1695-706
All references(57)
Disease annotation references (1)
Other
accession IDs
MGI:2138177, MGI:2140801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory