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Atg16l1
Gene Detail
 Symbol
Name
ID
Atg16l1
autophagy related 16-like 1 (S. cerevisiae)
MGI:1924290
Synonyms 1500009K01Rik, APG16L, WDR30
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:87755870-87792428 bp, + strand
From VEGA annotation of GRCm38

  36559 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atg16l1

Human
homologs
Human Homolog ATG16L1, autophagy related 16-like 1 (S. cerevisiae)
NCBI Gene ID 55054
neXtProt AC  NX_Q676U5
Human Synonyms  APG16L, ATG16A, ATG16L, IBD10, WDR30
Human Chr (Location)  2q37.1; chr2:233251571-233295674 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ATG16L1
Alleles
and
phenotypes
All alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozygotes have a cellular defect in autophagy that results in lethality during the neonatal starvation period. Mice homozygous for hypomorphic alleles have Paneth cells with aberrant, disorganized granules similar to those found in patients with Crohn's disease.
 
Human Diseases Modeled Using Mouse Atg16l1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component autophagic vacuole, autophagic vacuole membrane, ...
Function identical protein binding, protein binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (42)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 42
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016467 (Evidence)
Ensembl Gene ModelENSMUSG00000026289 (Evidence)
Entrez Gene77040 (Evidence)
DFCITC1575367, TC1592231, TC1595114, TC1602002, TC1602649, TC1606623, TC1646272
DoTSDT.101394504, DT.101707747, DT.101720679, DT.110932139, DT.55141134, DT.87042734, DT.91342401, DT.94281541, DT.97393709, DT.99860478
NIA Mouse Gene IndexU000563
Consensus CDS ProjectCCDS15136.1, CCDS56637.1, CCDS56638.1
International Mouse Knockout Project StatusAtg16l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016467 VEGA Gene Model | MGI Sequence Detail 36559 C57BL/6J ±  kb
transcript OTTMUST00000039678 VEGA | MGI Sequence Detail 3102 Not Applicable 
polypeptide OTTMUSP00000017709 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(9) UniProt(5)
Polymorphisms SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013923 Autophagy-related protein 16
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004409 autophagy-related protein 16-1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206800 Pirooz SD, et al., UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2716-21
All references(53)
Other
accession IDs
MGI:2138177, MGI:2140801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory