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Atg16l1 Gene Detail
Summary
  • Symbol
    Atg16l1
  • Name
    autophagy related 16-like 1 (S. cerevisiae)
  • Synonyms
    1500009K01Rik, APG16L, WDR30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924290
    NCBI Gene: 77040
  • Gene Overview
    MyGene.info: ATG16L1
Location & Maps
more
  • Sequence Map
    Chr1:87755870-87792428 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36559 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.44 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATG16L1, autophagy related 16 like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATG16L1, autophagy related 16 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APG16L, ATG16A, ATG16L, IBD10, WDR30
  • Links
    NCBI Gene ID: 55054
    neXtProt AC: NX_Q676U5

  • Chr Location
    2q37.1; chr2:233251571-233295674 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Atg16l1 mouse models; 1 with human ATG16L1 associations

Human Disease Mouse Models
       Inflammatory Bowel Disease (crohn Disease) 10; IBD10   OMIM: 611081 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 8 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Atg16l1
  • Incidental Mutations
Null homozygotes have a cellular defect in autophagy that results in lethality during the neonatal starvation period. Mice homozygous for hypomorphic alleles have Paneth cells with aberrant, disorganized granules similar to those found in patients with Crohn's disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016467 VEGA Gene Model | MGI Sequence Detail 36559 C57BL/6J ±  kb
transcript OTTMUST00000039678 VEGA | MGI Sequence Detail 3102 Not Applicable  
polypeptide OTTMUSP00000017709 VEGA | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    166 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
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MGI:2138177, MGI:2140801
References
more
  • Summaries
    All 57
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231079 Kabat AM, et al., The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory