Atg16l1
Gene Detail

Symbol Name ID

Atg16l1 autophagy related 16-like 1 (S. cerevisiae) MGI:1924290

Synonyms

1500009K01Rik, APG16L, WDR30

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:87755870-87792428 bp, + strand From VEGA annotation of GRCm38   36559 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41786  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atg16l1

Human homologs

Human Homolog		ATG16L1, autophagy related 16-like 1 (S. cerevisiae)
NCBI Gene ID		55054
neXtProt AC		NX_Q676U5
Human Synonyms		APG16L, ATG16A, ATG16L, IBD10, WDR30
Human Chr (Location)		2q37.1; chr2:234160217-234204320 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ATG16L1

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)
 

Null homozygotes have a cellular defect in autophagy that results in lethality during the neonatal starvation period. Mice homozygous for hypomorphic alleles have Paneth cells with aberrant, disorganized granules similar to those found in patients with Crohn's disease.

 
Human Diseases Modeled Using Mouse Atg16l1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	autophagic vacuole assembly, autophagy, ...
Component	autophagic vacuole, autophagic vacuole membrane, ...
Function	protein binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (42)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42

cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(76)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016467 (Evidence)
Ensembl Gene Model	ENSMUSG00000026289 (Evidence)
Entrez Gene	77040 (Evidence)
UniGene	272972
DFCI	TC1575367, TC1592231, TC1595114, TC1602002, TC1602649, TC1606623, TC1646272
DoTS	DT.101394504, DT.101707747, DT.101720679, DT.110932139, DT.55141134, DT.87042734, DT.91342401, DT.94281541, DT.97393709, DT.99860478
NIA Mouse Gene Index	U000563
Consensus CDS Project	CCDS15136.1, CCDS56637.1, CCDS56638.1
International Mouse Knockout Project Status	Atg16l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016467	VEGA Gene Model | MGI Sequence Detail	36559	C57BL/6J
transcript	OTTMUST00000039678	VEGA | MGI Sequence Detail	3102	Not Applicable
polypeptide	OTTMUSP00000017709	VEGA | MGI Sequence Detail	623	Not Applicable

All sequences(86) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(146 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013923	Autophagy-related protein 16
InterPro	IPR020472	G-protein beta WD-40 repeat
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000004409	autophagy-related protein 16-1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:181308 He C, et al., Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012 Jan 26;481(7382):511-5
All references(46)

Other accession IDs

MGI:2138177, MGI:2140801