About   Help   FAQ
Brd1
Gene Detail
Symbol

Name
ID
Brd1
bromodomain containing 1
MGI:1924161
Synonyms
1110059H06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:88687300-88734233 bp, - strand
From VEGA annotation of GRCm38

  46934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40956  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BRD1
Gene Tree: Brd1

Human
homologs
BRD1, bromodomain containing 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23774

Human Synonyms: BRL, BRPF1, BRPF2

Human Chr (Location): 22q13.33; chr22:49773278-49827548 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(109) : Gene trapped(105) Radiation induced(1) Targeted(3)
Genomic Mutations involving Brd1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit prenatal letahlity associated with severe growth retardation, abnormal lens, anemia, and impaired fetal hematopoiesis adn erythropoiesis.
 
Phenotype Images(2)
Interactions
Brd1 interacts with 346 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process histone H3 acetylation
Component dendrite, MOZ/MORF histone acetyltransferase complex, ...
Function histone binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (16)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 34
cDNA source data(106)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase brd1 ; ZFIN brd1a    NEW 
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017296 (Evidence)
Ensembl Gene Model ENSMUSG00000022387 (Evidence)
Entrez Gene 223770 (Evidence)
UniGene 254438
DFCI TC1604060, TC1601320, TC1597972, TC1581491
DoTS DT.94346583, DT.528241, DT.40180747, DT.94226988
NIA Mouse Gene Index U088676
Consensus CDS Project CCDS27730.2
International Mouse Phenotyping Consortium Status Brd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017296 VEGA Gene Model | MGI Sequence Detail 46934 C57BL/6J ±  kb
transcript OTTMUST00000041946 VEGA | MGI Sequence Detail 4886 Not Applicable 
polypeptide OTTMUSP00000018860 VEGA | MGI Sequence Detail 1189 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(14) UniProt(10)
Polymorphisms
SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR019542 Enhancer of polycomb-like, N-terminal
InterPro IPR000313 PWWP
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000029301 bromodomain-containing protein 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
All references(42)
Other
accession IDs
MGI:2145975

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory