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Brd1 Gene Detail
Summary
  • Symbol
    Brd1
  • Name
    bromodomain containing 1
  • Synonyms
    1110059H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924161
    NCBI Gene: 223770
Location & Maps
more
  • Sequence Map
    Chr15:88687300-88734233 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46934 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BRD1, bromodomain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRD1, bromodomain containing 1
    Orthology source: HomoloGene
  • Synonyms
    BRL, BRPF1, BRPF2
  • Links
    NCBI Gene ID: 23774
    neXtProt AC: NX_O95696

  • Chr Location
    22q13.33; chr22:49773278-49827548 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40956
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BRD1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    112
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    105
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Brd1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit prenatal letahlity associated with severe growth retardation, abnormal lens, anemia, and impaired fetal hematopoiesis adn erythropoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017296 VEGA Gene Model | MGI Sequence Detail 46934 C57BL/6J ±  kb
transcript OTTMUST00000041946 VEGA | MGI Sequence Detail 4886 Not Applicable  
polypeptide OTTMUSP00000018860 VEGA | MGI Sequence Detail 1189 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    223 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 106
    cDNA 106

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145975
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 30
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory