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Brd1 Gene Detail
Summary
  • Symbol
    Brd1
  • Name
    bromodomain containing 1
  • Synonyms
    1110059H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924161
    NCBI Gene: 223770
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:88687300-88734233 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46934 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.17 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BRD1, bromodomain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRD1, bromodomain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRL, BRPF1, BRPF2
  • Links
    NCBI Gene ID: 23774
    neXtProt AC: NX_O95696
    UniProt: O95696

  • Chr Location
    22q13.33; chr22:49773278-49827927 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 40956
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRD1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal letahlity associated with severe growth retardation, abnormal lens, anemia, and impaired fetal hematopoiesis and erythropoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017296 VEGA Gene Model | MGI Sequence Detail 46934 C57BL/6J ±  kb
    transcript OTTMUST00000041946 VEGA | MGI Sequence Detail 4886 Not Applicable  
    polypeptide OTTMUSP00000018860 VEGA | MGI Sequence Detail 1189 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      223 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 106

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145975
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 3
      Phenotypes 32
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7:40692

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory