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Brd1
Gene Detail
 Symbol
Name
ID
Brd1
bromodomain containing 1
MGI:1924161
Synonyms 1110059H06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 15
44.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:88687300-88734233 bp, - strand
From VEGA annotation of GRCm38

  46934 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40956  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Brd1

Human
homologs
Human Homolog BRD1, bromodomain containing 1
NCBI Gene ID 23774
neXtProt AC  NX_O95696
Human Synonyms  BRL, BRPF1, BRPF2
Human Chr (Location)  22q13.33; chr22:49773283-49827548 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(109) : Gene trapped(105) Radiation induced(1) Targeted(3)
Genomic Mutations involving Brd1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit prenatal letahlity associated with severe growth retardation, abnormal lens, anemia, and impaired fetal hematopoiesis adn erythropoiesis.
 
Interactions
Brd1 interacts with 347 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process histone H3 acetylation
Component MOZ/MORF histone acetyltransferase complex, nucleus
Function histone binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (16)    Images (12)
Theiler Stages: 23
Assay TypeResults
RNA in situ 34
cDNA source data(106)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017296 (Evidence)
Ensembl Gene ModelENSMUSG00000022387 (Evidence)
Entrez Gene223770 (Evidence)
UniGene254438
DFCITC1581491, TC1597972, TC1601320, TC1604060
DoTSDT.40180747, DT.528241, DT.94226988, DT.94346583
NIA Mouse Gene IndexU088676
Consensus CDS ProjectCCDS27730.2
International Mouse Knockout Project StatusBrd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017296 VEGA Gene Model | MGI Sequence Detail 46934 C57BL/6J ±  kb
transcript OTTMUST00000041946 VEGA | MGI Sequence Detail 4886 Not Applicable 
polypeptide OTTMUSP00000018860 VEGA | MGI Sequence Detail 1189 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(14) UniProt(11)
Polymorphisms SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR019542 Enhancer of polycomb-like, N-terminal
InterPro IPR000313 PWWP
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000029301 bromodomain-containing protein 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
All references(44)
Other
accession IDs
MGI:2145975

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory