Pbrm1
Gene Detail

Symbol

Name
ID

Pbrm1
polybromo 1
MGI:1923998

Synonyms

2310032M22Rik, 2610016F04Rik, BAF180, Pb1

Feature Type

protein coding gene

Genetic Map

Chromosome 14
19.09 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:31019138-31121592 bp, + strand From VEGA annotation of GRCm38   102455 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:10044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pbrm1

Human
homologs

Human Homolog		PBRM1, polybromo 1
NCBI Gene ID		55193
neXtProt AC		NX_Q86U86
Human Synonyms		BAF180, PB1
Human Chr (Location)		3p21; chr3:52545352-52685850 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.

 

Interactions

Pbrm1 interacts with 410 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (18 annotations)

Process	blood vessel remodeling, cardiac vascular smooth muscle cell development, ...
Component	BAF-type complex, kinetochore, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (32)    Tissues (30)    Images (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	24
RT-PCR	8

cDNA source data(224)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(225) cDNA(224) Primer pair(1)
Microarray probesets(10)

Other database
links

VEGA Gene Model	OTTMUSG00000023870 (Evidence)
Ensembl Gene Model	ENSMUSG00000042323 (Evidence)
Entrez Gene	66923 (Evidence)
UniGene	27913
DFCI	TC1616464, TC1602145, TC1599829, TC1597474, TC1691034, TC1685863, TC1583997, TC1585217
DoTS	DT.94339952, DT.40169659, DT.101383691, DT.101326729, DT.94200794, DT.91573582, DT.489360, DT.496547, DT.97406627
NIA Mouse Gene Index	U043388
PDB	2YQD
Consensus CDS Project	CCDS36851.1
International Mouse Knockout Project Status	Pbrm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023870	VEGA Gene Model | MGI Sequence Detail	102455	C57BL/6J
transcript	OTTMUST00000058317	VEGA | MGI Sequence Detail	6212	Not Applicable
polypeptide	OTTMUSP00000028240	VEGA | MGI Sequence Detail	1689	Not Applicable

All sequences(180) RefSeq(53) UniProt(16)

Polymorphisms

SNPs within 2kb(236 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001025	Bromo adjacent homology (BAH) domain
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR009071	High mobility group (HMG) box domain
Protein Ontology	PR:000012325	protein polybromo-1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212358 Singh AP, et al., Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
All references(59)

Other
accession IDs

MGI:1914173, MGI:2145667