Pbrm1
Gene Detail

Symbol Name ID

Pbrm1 polybromo 1 MGI:1923998

Synonyms

2310032M22Rik, 2610016F04Rik, BAF180, Pb1

Feature Type

protein coding gene

Genetic Map

Chromosome 14

19.09 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:31019138-31121592 bp, + strand From VEGA annotation of GRCm38   102455 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pbrm1

Human homologs

Human Homolog		PBRM1, polybromo 1
NCBI Gene ID		55193
neXtProt AC		NX_Q86U86
Human Synonyms		BAF180, PB1
Human Chr (Location)		3p21; chr3:52545352-52685850 (-)  GRCh38

Alleles and phenotypes

All alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	blood vessel remodeling, cardiac vascular smooth muscle cell development, ...
Component	kinetochore, nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (39)    Tissues (35)    Images (3)
Theiler Stages: 2, 3, 4, 5, 17, 23, 28

Assay Type	Results
RNA in situ	24
RT-PCR	15

cDNA source data(224)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(225) cDNA(224) Primer pair(1)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000023870 (Evidence)
Ensembl Gene Model	ENSMUSG00000042323 (Evidence)
Entrez Gene	66923 (Evidence)
UniGene	27913
DFCI	TC1583997, TC1585217, TC1597474, TC1599829, TC1602145, TC1616464, TC1685863, TC1691034
DoTS	DT.101326729, DT.101383691, DT.40169659, DT.489360, DT.496547, DT.91573582, DT.94200794, DT.94339952, DT.97406627
NIA Mouse Gene Index	U043388
PDB	2YQD
Consensus CDS Project	CCDS36851.1
International Mouse Knockout Project Status	Pbrm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023870	VEGA Gene Model | MGI Sequence Detail	102455	C57BL/6J
transcript	OTTMUST00000058317	VEGA | MGI Sequence Detail	6212	Not Applicable
polypeptide	OTTMUSP00000028240	VEGA | MGI Sequence Detail	1689	Not Applicable

All sequences(182) RefSeq(55) UniProt(16)

Polymorphisms

SNPs within 2kb(236 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001025	Bromo adjacent homology (BAH) domain
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR009071	High mobility group (HMG) box domain
Protein Ontology	PR:000012325	protein polybromo-1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
All references(58)

Other accession IDs

MGI:1914173, MGI:2145667