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Pbrm1
Gene Detail
Symbol

Name
ID
Pbrm1
polybromo 1
MGI:1923998
Synonyms
2310032M22Rik, 2610016F04Rik, BAF180, Pb1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
19.09 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:31019138-31121592 bp, + strand
From VEGA annotation of GRCm38

  102455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pbrm1

Human
homologs
Human Homolog PBRM1, polybromo 1
NCBI Gene ID 55193
neXtProt AC  NX_Q86U86
Human Synonyms  BAF180, PB1
Human Chr (Location)  3p21; chr3:52545352-52685850 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality with hypoplastic cardiac ventricular chambers and malformation of the placenta.
 
Interactions
Pbrm1 interacts with 410 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process blood vessel remodeling, cardiac vascular smooth muscle cell development, ...
Component kinetochore, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (32)    Tissues (30)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(224)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(225) cDNA(224) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000023870 (Evidence)
Ensembl Gene ModelENSMUSG00000042323 (Evidence)
Entrez Gene66923 (Evidence)
UniGene27913
DFCITC1583997, TC1585217, TC1597474, TC1599829, TC1602145, TC1616464, TC1685863, TC1691034
DoTSDT.101326729, DT.101383691, DT.40169659, DT.489360, DT.496547, DT.91573582, DT.94200794, DT.94339952, DT.97406627
NIA Mouse Gene IndexU043388
PDB2YQD
Consensus CDS ProjectCCDS36851.1
International Mouse Knockout Project StatusPbrm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023870 VEGA Gene Model | MGI Sequence Detail 102455 C57BL/6J ±  kb
transcript OTTMUST00000058317 VEGA | MGI Sequence Detail 6212 Not Applicable 
polypeptide OTTMUSP00000028240 VEGA | MGI Sequence Detail 1689 Not Applicable 

For the selected sequences
All sequences(182) RefSeq(55) UniProt(16)
Polymorphisms
SNPs within 2kb(236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000012325 protein polybromo-1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
All references(58)
Other
accession IDs
MGI:1914173, MGI:2145667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory