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Msi2 Gene Detail
Summary
  • Symbol
    Msi2
  • Name
    musashi RNA-binding protein 2
  • Synonyms
    msi2h, Musashi2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923876
    NCBI Gene: 76626
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:88339382-88718513 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      379132 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.40 cM, cytoband B5-C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MSI2, musashi RNA binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MSI2, musashi RNA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSI2H
  • Links
    NCBI Gene ID: 124540
    neXtProt AC: NX_Q96DH6
    UniProt: Q96DH6

  • Chr Location
    17q22; chr17:57255851-57684689 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit lethality, decreased body size, and decreased hematopoietic stem cells. Mice homozygous for a conditional knock-out allele exhibit impaired hematopoietic stem cell physiology upon induction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008130 VEGA Gene Model | MGI Sequence Detail 379132 C57BL/6J ±  kb
    transcript OTTMUST00000018479 VEGA | MGI Sequence Detail 1855 Not Applicable  
    polypeptide OTTMUSP00000008492 VEGA | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3907 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010672 RNA-binding protein Musashi homolog 2
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR034130 RNA-binding protein Musashi homologue, RNA recognition motif 1
      IPR034126 RNA-binding protein Musashi homologue, RNA recognition motif 2
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 27
      Primer pair 2
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2144175, MGI:2144227, MGI:2144536
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7(None):40692

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory