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Mfsd2a
Gene Detail
Symbol

Name
ID
Mfsd2a
major facilitator superfamily domain containing 2A
MGI:1923824
Synonyms
1700018O18Rik, Mfsd2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.34 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:122946850-122961188 bp, - strand
From VEGA annotation of GRCm38

  14339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MFSD2A
Gene Tree: Mfsd2a

Human
homologs
MFSD2A, major facilitator superfamily domain containing 2A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84879
neXtProt AC: NX_Q8NA29

Human Synonyms: MFSD2, NLS1

Human Chr (Location): 1p34.2; chr1:39955112-39969968 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Genomic Mutations involving Mfsd2a (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mic homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body weight, pronounced ataxia and altered metabolism.
 
Phenotype Images(3)
Interactions
Mfsd2a interacts with 160 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process establishment of blood-brain barrier, fatty acid transport, ...
Component cytoplasm, endoplasmic reticulum, ...
Function phospholipid transporter activity, symporter activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (83)    Tissues (15)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mfsd2a ; ZFIN mfsd2aa    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008939 (Evidence)
Ensembl Gene Model ENSMUSG00000028655 (Evidence)
Entrez Gene 76574 (Evidence)
UniGene 331842
DFCI TC1577655
DoTS DT.60118540
NIA Mouse Gene Index U025490
Consensus CDS Project CCDS18605.1
International Mouse Phenotyping Consortium Status Mfsd2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008939 VEGA Gene Model | MGI Sequence Detail 14339 C57BL/6J ±  kb
transcript OTTMUST00000020307 VEGA | MGI Sequence Detail 2151 Not Applicable 
polypeptide OTTMUSP00000009315 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000032118 major facilitator superfamily domain-containing protein 2A
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210589 Ben-Zvi A, et al., Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014 May 22;509(7501):507-11
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory