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Rftn1
Gene Detail
Symbol

Name
ID
Rftn1
raftlin lipid raft linker 1
MGI:1923688
Synonyms
2310015N21Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
25.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:49992257-50190674 bp, - strand
From VEGA annotation of GRCm38

  198418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18745  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Rftn1

Human
homologs
Human Homolog RFTN1, raftlin, lipid raft linker 1
NCBI Gene ID 23180
neXtProt AC  NX_Q14699
Human Synonyms  PIB10, PIG9, RAFTLIN
Human Chr (Location)  3p24.3; chr3:16315845-16513715 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations have defects in T cell activation, T cell help to B cells, and Th17 differentation.
 
Interactions
Rftn1 interacts with 242 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process B cell receptor signaling pathway, dsRNA transport, ...
Component cell, cytoplasm, ...
Function double-stranded RNA binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (68)    Tissues (9)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 68
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023326 (Evidence)
Ensembl Gene ModelENSMUSG00000039316 (Evidence)
Entrez Gene76438 (Evidence)
UniGene41854
DFCITC1579049, TC1597275, TC1767813
DoTSDT.101138462, DT.99696858, DT.99702419
NIA Mouse Gene IndexU037905
Consensus CDS ProjectCCDS28873.1
International Mouse Knockout Project StatusRftn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023326 VEGA Gene Model | MGI Sequence Detail 198418 C57BL/6J ±  kb
transcript OTTMUST00000056511 VEGA | MGI Sequence Detail 4029 Not Applicable 
polypeptide OTTMUSP00000027168 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(1195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000013920 raftlin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:170947 Watanabe A, et al., Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation. J Biol Chem. 2011 Mar 25;286(12):10702-11
All references(31)
Other
accession IDs
MGI:2146943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory