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Sephs1 Gene Detail
Summary
  • Symbol
    Sephs1
  • Name
    selenophosphate synthetase 1
  • Synonyms
    1110046B24Rik, SPS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923580
    NCBI Gene: 109079
  • Gene Overview
    MyGene.info: SEPHS1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:4881564-4910557 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 3.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923580
protein coding gene Chr2:4881564-4910557 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025316
protein coding gene Chr2:1954443-1989973 (+)
A/J MGP_AJ_G0025293
protein coding gene Chr2:1860530-1890009 (+)
AKR/J MGP_AKRJ_G0025261
protein coding gene Chr2:1896241-1928365 (+)
BALB/cJ MGP_BALBcJ_G0025289
protein coding gene Chr2:1838317-1871804 (+)
C3H/HeJ MGP_C3HHeJ_G0025049
protein coding gene Chr2:1883813-1920301 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025731
protein coding gene Chr2:1972879-2006434 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023145
protein coding gene Chr2:1713939-1740056 (+)
CAST/EiJ MGP_CASTEiJ_G0024512
protein coding gene Chr2:1910963-1945518 (+)
CBA/J MGP_CBAJ_G0025028
protein coding gene Chr2:2052470-2090232 (+)
DBA/2J MGP_DBA2J_G0025160
protein coding gene Chr2:1829488-1858918 (+)
FVB/NJ MGP_FVBNJ_G0025122
protein coding gene Chr2:1817503-1848218 (+)
LP/J MGP_LPJ_G0025246
protein coding gene Chr2:1935148-1967880 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025154
protein coding gene Chr2:1958161-1992699 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025789
protein coding gene Chr2:1898365-1933008 (+)
PWK/PhJ MGP_PWKPhJ_G0024262
protein coding gene Chr2:1810736-1840387 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024063
protein coding gene Chr2:1906381-1934922 (+)
WSB/EiJ MGP_WSBEiJ_G0024582
protein coding gene Chr2:1919543-1951979 (+)



Homology
more
  • Human Ortholog
    SEPHS1, selenophosphate synthetase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEPHS1, selenophosphate synthetase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SELD, SPS, SPS1
  • Links
    NCBI Gene ID: 22929
    neXtProt AC: NX_P49903
    UniProt: P49903

  • Chr Location
    10p13; chr10:13317428-13348298 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth retardation and complete lethality by E14.5 with failure of the amnion to separate from the yolk sac. Mice homozygous for a conditional allele activated in the liver exhibit reduced liver iron and manganese levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109079 NCBI Gene Model | MGI Sequence Detail 28994 C57BL/6J ±  kb
    transcript NM_001362707 RefSeq | MGI Sequence Detail 5381 Not Specified  
    polypeptide Q8BH69 UniProt | EBI | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 139

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2138799, MGI:2138992, MGI:2139306
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:245139 Tobe R, et al., Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochem J. 2016 Jul 15;473(14):2141-54

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory