Sequence Detail

ID/Version

Q8BH69 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Selenide, water dikinase 1; EC=2.7.9.3 {ECO:0000250|UniProtKB:P97364};AltName: Full=Selenium donor protein 1;AltName: Full=Selenophosphate synthase 1 {ECO:0000303|PubMed:17346238};

Provider

SWISS-PROT

Sequence

Polypeptide 392 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sephs1	selenophosphate synthetase 1	27	98	3	39

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121763 Xu XM, et al., Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem J. 2007 May 15;404(1):115-20
J:121949 Xu XM, et al., Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 2006 Dec;5(1):e4
J:245139 Tobe R, et al., Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochem J. 2016 Jul 15;473(14):2141-54
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314663 Bang J, et al., Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1(-/-) Mice. Int J Mol Sci. 2021 Oct 28;22(21)
J:322233 Kang D, et al., Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis. Nat Commun. 2022 Feb 9;13(1):779
J:330358 Qiao L, et al., SEPHS1 is dispensable for pluripotency maintenance but indispensable for cardiac differentiation in mouse embryonic stem cells. Biochem Biophys Res Commun. 2022 Jan 29;590:125-131
J:371655 Jung J, et al., Constitutive Oxidative Stress by SEPHS1 Deficiency Induces Endothelial Cell Dysfunction. Int J Mol Sci. 2021 Oct 28;22(21)