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Trafd1 Gene Detail
Summary
  • Symbol
    Trafd1
  • Name
    TRAF type zinc finger domain containing 1
  • Synonyms
    1110008K06Rik, Fln29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923551
    NCBI Gene: 231712
  • Gene Overview
    MyGene.info: TRAFD1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121371725-121385627 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923551
protein coding gene Chr5:121371725-121385632 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030025
protein coding gene Chr5:124847148-124860831 (-)
A/J MGP_AJ_G0029990
protein coding gene Chr5:119712592-119726959 (-)
AKR/J MGP_AKRJ_G0029927
protein coding gene Chr5:123586667-123600816 (-)
BALB/cJ MGP_BALBcJ_G0030001
protein coding gene Chr5:121096051-121110243 (-)
C3H/HeJ MGP_C3HHeJ_G0029719
protein coding gene Chr5:124147719-124161442 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030454
protein coding gene Chr5:129607159-129623908 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027680
protein coding gene Chr5:114391366-114406189 (-)
CAST/EiJ MGP_CASTEiJ_G0029127
protein coding gene Chr5:123260584-123275119 (-)
CBA/J MGP_CBAJ_G0029688
protein coding gene Chr5:134689428-134705266 (-)
DBA/2J MGP_DBA2J_G0029838
protein coding gene Chr5:119784485-119798386 (-)
FVB/NJ MGP_FVBNJ_G0029795
protein coding gene Chr5:118731458-118746950 (-)
LP/J MGP_LPJ_G0029927
protein coding gene Chr5:125371452-125385209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029825
protein coding gene Chr5:138570382-138584741 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030495
protein coding gene Chr5:123095279-123109422 (-)
PWK/PhJ MGP_PWKPhJ_G0028841
protein coding gene Chr5:118551969-118566163 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028678
protein coding gene Chr5:120857808-120872803 (-)
WSB/EiJ MGP_WSBEiJ_G0029202
protein coding gene Chr5:123755889-123770602 (-)



Homology
more
  • Human Ortholog
    TRAFD1, TRAF-type zinc finger domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRAFD1, TRAF-type zinc finger domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLN29
  • Links
    NCBI Gene ID: 10906
    neXtProt AC: NX_O14545
    UniProt: O14545

  • Chr Location
    12q24.13; chr12:112125545-112153604 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to endotoxin shock and decreased susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231712 NCBI Gene Model | MGI Sequence Detail 13903 C57BL/6J ±  kb
    transcript NM_001163470 RefSeq | MGI Sequence Detail 2498 C57BL/6  
    polypeptide Q3UDK1 UniProt | EBI | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 117

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory