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Erp44 Gene Detail
Summary
  • Symbol
    Erp44
  • Name
    endoplasmic reticulum protein 44
  • Synonyms
    1110001E24Rik, Txndc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923549
    NCBI Gene: 76299
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:48193323-48279558 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 26.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923549
protein coding gene Chr4:48190711-48279635 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028272
protein coding gene Chr4:46611626-46699219 (-)
A/J MGP_AJ_G0028231
protein coding gene Chr4:44868447-44956057 (-)
AKR/J MGP_AKRJ_G0028181
protein coding gene Chr4:46008912-46099071 (-)
BALB/cJ MGP_BALBcJ_G0028251
protein coding gene Chr4:44984805-45072166 (-)
C3H/HeJ MGP_C3HHeJ_G0027972
protein coding gene Chr4:46584943-46670119 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028692
protein coding gene Chr4:48294701-48387772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026001
protein coding gene Chr4:42222647-42306940 (-)
CAST/EiJ MGP_CASTEiJ_G0027411
protein coding gene Chr4:46170501-46263505 (-)
CBA/J MGP_CBAJ_G0027938
protein coding gene Chr4:49852417-49943512 (-)
DBA/2J MGP_DBA2J_G0028088
protein coding gene Chr4:44754062-44837504 (-)
FVB/NJ MGP_FVBNJ_G0028055
protein coding gene Chr4:44021763-44108479 (-)
LP/J MGP_LPJ_G0028187
protein coding gene Chr4:46662654-46750251 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028079
protein coding gene Chr4:52853542-52963852 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028727
protein coding gene Chr4:46201391-46290970 (-)
PWK/PhJ MGP_PWKPhJ_G0027136
protein coding gene Chr4:44873906-44960248 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026964
protein coding gene Chr4:45717559-45805870 (-)
WSB/EiJ MGP_WSBEiJ_G0027489
protein coding gene Chr4:46139440-46227185 (-)



Homology
more
  • Human Ortholog
    ERP44, endoplasmic reticulum protein 44
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERP44, endoplasmic reticulum protein 44
  • Synonyms
    PDIA10, TXNDC4
  • Links
    NCBI Gene ID: 23071
    neXtProt AC: NX_Q9BS26
    UniProt: Q9BS26

  • Chr Location
    9q31.1; chr9:99979185-100099052 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit light coat colour, small stature and scaly tail.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028343 Ensembl Gene Model | MGI Sequence Detail 86236 C57BL/6J ±  kb
    transcript ENSMUST00000030028 Ensembl | MGI Sequence Detail 2624 Not Applicable  
    polypeptide ENSMUSP00000030028 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016862 endoplasmic reticulum resident protein 44
    • InterPro Domains
      IPR041870 Endoplasmic reticulum resident protein 44, TRX-like domain b
      IPR041862 Endoplasmic reticulum resident protein 44, TRX-like domain b'
      IPR013766 Thioredoxin domain
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 150

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140383, MGI:2140418
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345334 Xie H, et al., SUMOylation of ERp44 enhances Ero1alpha ER retention contributing to the pathogenesis of obesity and insulin resistance. Metabolism. 2023 Feb;139:155351

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory