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Rsg1 Gene Detail
Summary
  • Symbol
    Rsg1
  • Name
    REM2 and RAB-like small GTPase 1
  • Synonyms
    6330545A04Rik, b2b2804Clo, b2b2827Clo, LOC279260
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923416
    NCBI Gene: 76166
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141213667-141220114 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923416
protein coding gene Chr4:141213667-141226756 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029041
protein coding gene Chr4:144242740-144255711 (+)
A/J MGP_AJ_G0029000
protein coding gene Chr4:137978496-137993176 (+)
AKR/J MGP_AKRJ_G0028952
protein coding gene Chr4:141960456-141973266 (+)
BALB/cJ MGP_BALBcJ_G0029024
protein coding gene Chr4:138671889-138684660 (+)
C3H/HeJ MGP_C3HHeJ_G0028738
protein coding gene Chr4:142333650-142346518 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029465
protein coding gene Chr4:149286442-149299182 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026736
protein coding gene Chr4:130890603-130897747 (+)
CAST/EiJ MGP_CASTEiJ_G0028170
protein coding gene Chr4:140590482-140604376 (+)
CBA/J MGP_CBAJ_G0028702
protein coding gene Chr4:153598464-153613616 (+)
DBA/2J MGP_DBA2J_G0028852
protein coding gene Chr4:138371483-138384766 (+)
FVB/NJ MGP_FVBNJ_G0028819
protein coding gene Chr4:137477040-137490658 (+)
LP/J MGP_LPJ_G0028951
protein coding gene Chr4:144253214-144275533 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028845
protein coding gene Chr4:157432840-157459179 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029503
protein coding gene Chr4:142483339-142496847 (+)
PWK/PhJ MGP_PWKPhJ_G0027891
protein coding gene Chr4:135257715-135271642 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027716
protein coding gene Chr4:138302636-138315836 (+)
WSB/EiJ MGP_WSBEiJ_G0028248
protein coding gene Chr4:142764538-142779864 (+)



Homology
more
  • Human Ortholog
    CPLANE2, ciliogenesis and planar polarity effector 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CPLANE2, ciliogenesis and planar polarity effector 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf89, RSG1
  • Links
    NCBI Gene ID: 79363
    neXtProt AC: NX_Q9BU20
    UniProt: Q9BU20

  • Chr Location
    1p36.13; chr1:16231687-16237445 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Rsg1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    21 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Rsg1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for ENU-induced mutations exhibit cardiovascular defects including persistent truncus arteriosus and atrioventricular septal defects, as well as polydactyly and micrognathia. Eye defects, hypoplastic lungs and thymus, and tracheoesophageal anomalies may be also present.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 76166 NCBI Gene Model | MGI Sequence Detail 6448 C57BL/6J ±  kb
transcript NM_001081174 RefSeq | MGI Sequence Detail 951 C57BL/6  
polypeptide A2A825 UniProt | EBI | MGI Sequence Detail 258 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685569, MGI:5560797, MGI:5616145
References
more
  • Summaries
    All 26
    Diseases 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:255486 Agbu SO, et al., The small GTPase RSG1 controls a final step in primary cilia initiation. J Cell Biol. 2018 Jan 2;217(1):413-427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/08/2019
MGI 6.13
The Jackson Laboratory