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Ppp1r14c Gene Detail
Summary
  • Symbol
    Ppp1r14c
  • Name
    protein phosphatase 1, regulatory inhibitor subunit 14C
  • Synonyms
    6330514J04Rik, KEPI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923392
    NCBI Gene: 76142
  • Gene Overview
    MyGene.info: PPP1R14C
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:3366071-3464975 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 2.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923392
protein coding gene Chr10:3366057-3464975 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016972
protein coding gene Chr10:279742-388069 (+)
A/J MGP_AJ_G0016950
protein coding gene Chr10:270951-370411 (+)
AKR/J MGP_AKRJ_G0016915
protein coding gene Chr10:236634-348678 (+)
BALB/cJ MGP_BALBcJ_G0016908
protein coding gene Chr10:241631-345056 (+)
C3H/HeJ MGP_C3HHeJ_G0016733
protein coding gene Chr10:300201-402630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017371
protein coding gene Chr10:260581-369937 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015077
protein coding gene Chr10:147468-240944 (+)
CAST/EiJ MGP_CASTEiJ_G0016315
protein coding gene Chr10:334854-440471 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0016813
protein coding gene Chr10:290020-390788 (+)
FVB/NJ MGP_FVBNJ_G0016808
protein coding gene Chr10:237739-341638 (+)
LP/J MGP_LPJ_G0016888
protein coding gene Chr10:283960-398511 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016839
protein coding gene Chr10:260893-368788 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017408
protein coding gene Chr10:243125-347690 (+)
PWK/PhJ MGP_PWKPhJ_G0016101
protein coding gene Chr10:283117-383602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015882
protein coding gene Chr10:446317-596222 (+)
WSB/EiJ MGP_WSBEiJ_G0016376
protein coding gene Chr10:297122-403098 (+)



Homology
more
  • Human Ortholog
    PPP1R14C, protein phosphatase 1 regulatory inhibitor subunit 14C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP1R14C, protein phosphatase 1 regulatory inhibitor subunit 14C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPI17-like, KEPI, NY-BR-81
  • Links
    NCBI Gene ID: 81706
    neXtProt AC: NX_Q8TAE6
    UniProt: Q8TAE6

  • Chr Location
    6q25.1; chr6:150143052-150250392 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit some prenatal lethality and enhanced behavioral response to morphine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 76142 NCBI Gene Model | MGI Sequence Detail 98905 C57BL/6J ±  kb
transcript NM_133485 RefSeq | MGI Sequence Detail 2524 C57BL/6  
polypeptide Q8R4S0 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory