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Targeted Allele Detail
Symbol: Ppp1r14ctm1Uhl
Name: protein phosphatase 1, regulatory inhibitor subunit 14C; targeted mutation 1, George R Uhl
MGI ID: MGI:4450989
Gene: Ppp1r14c  Location: Chr10:3316057-3414975 bp, + strand  Genetic Position: Chr10, 2.06 cM
Alliance: Ppp1r14ctm1Uhl page
Germline Transmission:  Earliest citation of germline transmission: J:159561
Parent Cell Line:  MC1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 1 was replaced with a neo cassette. RT-PCR confirmed the absence of transcript expression. (J:159561)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp1r14c Mutation:  13 strains or lines available
The original line on a mixed 129S6/SvEvTac and C57BL/6 background was discontinued in favor of a recombinant line containing regions adjacent to the targeted allele from C57BL/6 (J:159561).
Original:  J:159561 Drgonova J, et al., Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Neuroscience. 2010 Feb 3;165(3):882-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory