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Senp2 Gene Detail
Summary
  • Symbol
    Senp2
  • Name
    SUMO/sentrin specific peptidase 2
  • Synonyms
    2310007L05Rik, 4930538C18Rik, mKIAA1331
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923076
    NCBI Gene: 75826
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21828234-21868019 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.98 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    988 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923076
 protein coding gene Chr16:21828182-21868019 (+)
129S1/SvImJ ENSMUSG00200043295
 protein coding gene Chr16:18827813-18867598 (+)
A/J ENSMUSG00195029987
 protein coding gene Chr16:18386124-18425913 (+)
AKR/J ENSMUSG00220035369
 protein coding gene Chr16:18705567-18745345 (+)
BALB/cJ ENSMUSG00180037805
 protein coding gene Chr16:18626722-18666516 (+)
C3H/HeJ ENSMUSG00175048842
 protein coding gene Chr16:18771682-18811470 (+)
C57BL/6NJ ENSMUSG00215038912
 protein coding gene Chr16:18498898-18538669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020600
 protein coding gene Chr16:19235460-19275391 (+)
CAST/EiJ ENSTCUG00005042829
 protein coding gene Chr16:19106215-19144910 (+)
CBA/J ENSMUSG00210034762
 protein coding gene Chr16:18793435-18833224 (+)
DBA/2J ENSMUSG00185029555
 protein coding gene Chr16:18732193-18771979 (+)
FVB/NJ ENSMUSG00205020770
 protein coding gene Chr16:18728024-18767815 (+)
JF1/MsJ ENSUMUG00000036080
 protein coding gene Chr16:18949978-18988102 (+)
LP/J ENSMUSG00230031802
 protein coding gene Chr16:21311345-21351135 (+)
NOD/ShiLtJ ENSMUSG00190036293
 protein coding gene Chr16:18873674-18913460 (+)
NZO/HlLtJ ENSMUSG00225037201
 protein coding gene Chr16:24562416-24602201 (+)
PWK/PhJ ENSLUMG00010044117
 protein coding gene Chr16:18775841-18813885 (+)
SPRET/EiJ ENSMSPG00010036121
 protein coding gene Chr16:18649981-18690535 (+)
WSB/EiJ ENSIUOG00005039146
 protein coding gene Chr16:18952065-18991870 (+)



Homology
more
  • Human Ortholog
    SENP2, SUMO specific peptidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SENP2, SUMO specific peptidase 2
  • Synonyms
    AXAM2, SMT3IP2
  • Links
    NCBI Gene ID: 59343
    UniProt: Q9HC62

  • Chr Location
    3q27.2; chr3:185582496-185633551 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 5 alleles in 5 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are embryonic lethal due to placental defects resulting from abnormal trophoblast maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    53
  • cDNA Data
    8
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022855 Ensembl Gene Model | MGI Sequence Detail 39786 C57BL/6J ±  kb
    transcript ENSMUST00000023561 Ensembl | MGI Sequence Detail 4499 Not Applicable  
    polypeptide ENSMUSP00000023561 Ensembl | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 8
      Primer pair 5
      Other 1
      Antibodies 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916738, MGI:2146470, MGI:2146665
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 12
      Gene Ontology 15
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353924 Yang TT, et al., SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis. Commun Biol. 2023 Jun 10;6(1):629
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory