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Senp2 Gene Detail
Summary
  • Symbol
    Senp2
  • Name
    SUMO/sentrin specific peptidase 2
  • Synonyms
    2310007L05Rik, 4930538C18Rik, mKIAA1331
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923076
    NCBI Gene: 75826
  • Gene Overview
    MyGene.info: SENP2
Location & Maps
more
  • Sequence Map
    Chr16:22009484-22049269 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39786 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.98 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SENP2, SUMO1/sentrin/SMT3 specific peptidase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SENP2, SUMO1/sentrin/SMT3 specific peptidase 2
    Orthology source: HomoloGene
  • Synonyms
    AXAM2, SMT3IP2
  • Links
    NCBI Gene ID: 59343
    neXtProt AC: NX_Q9HC62

  • Chr Location
    3q27.2; chr3:185586228-185631101 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 5 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are embryonic lethal due to placental defects resulting from abnormal trophoblast maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022855 Ensembl Gene Model | MGI Sequence Detail 39786 C57BL/6J ±  kb
transcript ENSMUST00000023561 Ensembl | MGI Sequence Detail 4499 Not Applicable  
polypeptide ENSMUSP00000023561 Ensembl | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    168 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014636 sentrin-specific protease 2
  • EC
  • InterPro Domains
    IPR003653 Ulp1 protease family, C-terminal catalytic domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 7
Other
Accession IDs
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MGI:1916738, MGI:2146470, MGI:2146665
References
more
  • Summaries
    All 48
    Developmental Gene Expression 8
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory