Gene Expression Literature Summary

• Symbol: Senp2
• Name: SUMO/sentrin specific peptidase 2
• ID: MGI:1923076

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2.5	E3.5	E4.5	E7	E7.5	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)											1			1	1	1	1	2		1
In situ RNA (section)					1	1	1		1		1	1			1	1						3
In situ reporter (knock in)	1	1	1	1				1		1	1
Western blot									1				1		1		1		1			3
RT-PCR									1		3	1			1		1				2	2
cDNA clones																						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Senp2  SUMO/sentrin specific peptidase 2   (Synonyms: 2310007L05Rik, 4930538C18Rik, mKIAA1331)
Results	Reference
7	J:144707 Chiu SY, Asai N, Costantini F, Hsu W, SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16;6(12):e310
4*	J:224530 Dietrich JE, Panavaite L, Gunther S, Wennekamp S, Groner AC, Pigge A, Salvenmoser S, Trono D, Hufnagel L, Hiiragi T, Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21
3*	J:228859 Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W, Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. PLoS Genet. 2014 Oct;10(10):e1004579
6	J:315590 Fujiwara K, Hasegawa K, Oka M, Yoneda Y, Yoshikawa K, Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system. Genes Cells. 2016 Nov;21(11):1176-1194
1	J:162938 Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET, SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23;38(2):191-201
6	J:183651 Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J, Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012 Mar;52(3):638-49
3	J:294283 Liang Q, Zheng Q, Zuo Y, Chen Y, Ma J, Ni P, Cheng J, SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Rep. 2019 Aug 20;28(8):2004-2011.e4
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
5	J:250113 Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W, Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development. Sci Rep. 2016 Feb 17;6:20999
1	J:213037 Qi Y, Zuo Y, Yeh ET, Cheng J, An essential role of small ubiquitin-like modifier (SUMO)-specific Protease 2 in myostatin expression and myogenesis. J Biol Chem. 2014 Feb 7;289(6):3288-93
6*	J:298019 Zhang X, Wang C, Zhao D, Chen X, Zhang C, Zheng J, Liu X, Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression. PLoS One. 2020;15(11):e0242606