Nme5
Gene Detail

Symbol Name ID

Nme5 NME/NM23 family member 5 MGI:1922783

Synonyms

1700019D05Rik, Nm23-M5, non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

Feature Type

protein coding gene

Genetic Map

Chromosome 18

18.69 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:34562634-34579115 bp, - strand From VEGA annotation of GRCm38   16482 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2628  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nucleoside-diphosphate kinase homolog with Dpy-30 motif (NDK-H5)
Gene Tree: Nme5

Human homologs

Human Homolog		NME5, NME/NM23 family member 5
NCBI Gene ID		8382
neXtProt AC		NX_P56597
Human Synonyms		NM23H5, NM23-H5, RSPH23
Human Chr (Location)		5q31; chr5:137450861-137475132 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous mice exhibit hydrocephaly and male spermatogenesis defects.

 
Human Diseases Modeled Using Mouse Nme5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell differentiation, CTP biosynthetic process, ...
Component	sperm flagellum
Function	ATP binding, nucleoside diphosphate kinase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033174 (Evidence)
Ensembl Gene Model	ENSMUSG00000035984 (Evidence)
Entrez Gene	75533 (Evidence)
UniGene	275430
DFCI	TC1586114, TC1647606
DoTS	DT.101368808, DT.91338673, DT.94288401
NIA Mouse Gene Index	U038307
Consensus CDS Project	CCDS29130.1
International Mouse Knockout Project Status	Nme5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033174	VEGA Gene Model | MGI Sequence Detail	16482	C57BL/6J
transcript	OTTMUST00000082987	VEGA | MGI Sequence Detail	843	Not Applicable
polypeptide	OTTMUSP00000044531	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(36 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007858	Dpy-30 motif
InterPro	IPR001564	Nucleoside diphosphate kinase
InterPro	IPR012410	Nucleoside-diphosphate kinase-like NDK-H5
Protein Ontology	PR:000011285	nucleoside diphosphate kinase 5

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(35)