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Rspo2
Gene Detail
Symbol

Name
ID
Rspo2
R-spondin 2 homolog (Xenopus laevis)
MGI:1922667
Synonyms
2610028F08Rik, FLTL, ftls, Int7
Feature Type
protein coding gene
Genetic Map
Chromosome 15
16.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:43020811-43170818 bp, - strand
From Ensembl annotation of GRCm38

  150008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18235  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RSPO2
Gene Tree: Rspo2

Human
homologs
RSPO2, R-spondin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 340419
neXtProt AC: NX_Q6UXX9

Human Synonyms: CRISTIN2

Human Chr (Location): 8q23.1; chr8:107899316-108083685 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
 
Homozygous mice display perinatal lethality, cleft palate, lung hypoplasia, asymmetric limb malformations and abnormal renal development. Heterozygous females display reduced fertility with age.
 
Phenotype Images(2)
Interactions
Rspo2 interacts with 296 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process bone mineralization, dopaminergic neuron differentiation, ...
Component cell surface, extracellular region, ...
Function G-protein coupled receptor binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (357)    Tissues (251)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 353
RT-PCR 4
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RSPO2 ; Xenbase rspo2    NEW 
Molecular
reagents
All nucleic(39) cDNA(35) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000051920 (Evidence)
Entrez Gene 239405 (Evidence)
UniGene 193274
DFCI TC1581285, TC1590614, TC1678599
DoTS DT.101353072, DT.94272414, DT.97340695
NIA Mouse Gene Index U036135
PDB 4C99
Consensus CDS Project CCDS27451.1
International Mouse Phenotyping Consortium Status Rspo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051920 Ensembl Gene Model | MGI Sequence Detail 150008 C57BL/6J ±  kb
transcript ENSMUST00000063492 Ensembl | MGI Sequence Detail 3324 Not Applicable 
polypeptide ENSMUSP00000067325 Ensembl | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(1003 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000884 Thrombospondin type-1 (TSP1) repeat
Protein Ontology PR:000014331 R-spondin-2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210988 Kawasaki M, et al., R-spondins/Lgrs expression in tooth development. Dev Dyn. 2014 Jun;243(6):844-51
All references(53)
Other
accession IDs
MGI:2145926, MGI:3045969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory