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Rspo2
Gene Detail
 Symbol
Name
ID
Rspo2
R-spondin 2 homolog (Xenopus laevis)
MGI:1922667
Synonyms 2610028F08Rik, FLTL, ftls, Int7
Feature Type protein coding gene
Genetic Map
Chromosome 15
16.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:43020811-43170818 bp, - strand
From Ensembl annotation of GRCm38

  150008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18235  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rspo2

Human
homologs
Human Homolog RSPO2, R-spondin 2
NCBI Gene ID 340419
neXtProt AC  NX_Q6UXX9
Human Synonyms  CRISTIN2
Human Chr (Location)  8q23.1; chr8:107899316-108083685 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
 
Homozygous mice display perinatal lethality, cleft palate, lung hypoplasia, asymmetric limb malformations and abnormal renal development. Heterozygous females display reduced fertility with age.
 
Phenotype Images(2)
Interactions
Rspo2 interacts with 297 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process bone mineralization, embryonic forelimb morphogenesis, ...
Component cell surface, extracellular region
Function heparin binding, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (357)    Tissues (251)    Images (43)
Theiler Stages: 10, 11, 13, 15, 17, 18, 20, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 353
RT-PCR 4
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(35) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000051920 (Evidence)
Entrez Gene239405 (Evidence)
UniGene193274
DFCITC1581285, TC1590614, TC1678599
DoTSDT.101353072, DT.94272414, DT.97340695
NIA Mouse Gene IndexU036135
PDB4C99
Consensus CDS ProjectCCDS27451.1
International Mouse Knockout Project StatusRspo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051920 Ensembl Gene Model | MGI Sequence Detail 150008 C57BL/6J ±  kb
transcript ENSMUST00000063492 Ensembl | MGI Sequence Detail 3324 Not Applicable 
polypeptide ENSMUSP00000067325 Ensembl | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(1003 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000014331 R-spondin-2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210988 Kawasaki M, et al., R-spondins/Lgrs expression in tooth development. Dev Dyn. 2014 Jun;243(6):844-51
All references(52)
Other
accession IDs
MGI:2145926, MGI:3045969

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory