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Rspo2 Gene Detail
Summary
  • Symbol
    Rspo2
  • Name
    R-spondin 2
  • Synonyms
    2610028F08Rik, FLTL, ftls, Int7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922667
    NCBI Gene: 239405
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:42884190-43034222 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3948 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922667
 protein coding gene Chr15:42884184-43034990 (-)
129S1/SvImJ ENSMUSG00200026054
 protein coding gene Chr15:39836852-39979434 (-)
A/J ENSMUSG00195035436
 protein coding gene Chr15:39821069-39971245 (-)
AKR/J ENSMUSG00220026899
 protein coding gene Chr15:39756751-39910553 (-)
BALB/cJ ENSMUSG00180030368
 protein coding gene Chr15:39804550-39954688 (-)
C3H/HeJ ENSMUSG00175025670
 protein coding gene Chr15:40011076-40165422 (-)
C57BL/6NJ ENSMUSG00215016674
 protein coding gene Chr15:39796862-39946981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019767
 protein coding gene Chr15:37600042-37745445 (-)
CAST/EiJ ENSTCUG00005010625
 protein coding gene Chr15:39805203-39948543 (-)
CBA/J ENSMUSG00210017836
 protein coding gene Chr15:39945980-40095904 (-)
DBA/2J ENSMUSG00185031593
 protein coding gene Chr15:39918000-40067894 (-)
FVB/NJ ENSMUSG00205028635
 protein coding gene Chr15:39801443-39955063 (-)
JF1/MsJ ENSUMUG00000032413
 protein coding gene Chr15:39775892-39918490 (-)
LP/J ENSMUSG00230014267
 protein coding gene Chr15:43220646-43363182 (-)
NOD/ShiLtJ ENSMUSG00190023644
 protein coding gene Chr15:39884100-40034005 (-)
NZO/HlLtJ ENSMUSG00225037780
 protein coding gene Chr15:43596274-43746168 (-)
PWK/PhJ ENSLUMG00010028778
 protein coding gene Chr15:39935337-40078178 (-)
SPRET/EiJ ENSMSPG00010012634
 protein coding gene Chr15:40763916-40906986 (-)
WSB/EiJ ENSIUOG00005029934
 protein coding gene Chr15:39863693-40013877 (-)



Homology
more
  • Human Ortholog
    RSPO2, R-spondin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSPO2, R-spondin 2
  • Synonyms
    CRISTIN2, HHRRD, TETAMS2
  • Links
    NCBI Gene ID: 340419
    UniProt: Q6UXX9

  • Chr Location
    8q23.1; chr8:107899316-108083790 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RSPO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 4 alleles in 5 genetic backgrounds
    22 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display perinatal lethality, cleft palate, lung hypoplasia, asymmetric limb malformations and abnormal renal development. Heterozygous females display reduced fertility with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1170
  • Tissues
    347
  • cDNA Data
    38
  • Literature Summary
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051920 Ensembl Gene Model | MGI Sequence Detail 150033 C57BL/6J ±  kb
    transcript ENSMUST00000063492 Ensembl | MGI Sequence Detail 3338 Not Applicable  
    polypeptide ENSMUSP00000067325 Ensembl | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 38
      Primer pair 14
      Other 7
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145926, MGI:3045969
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 59
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory