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Stx11
Gene Detail
Symbol

Name
ID
Stx11
syntaxin 11
MGI:1921982
Synonyms
5830405C08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
4.54 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:12939983-12964259 bp, - strand
From Ensembl annotation of GRCm38

  24277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STX11
Protein SuperFamily: syntaxin
Gene Tree: Stx11

Human
homologs
STX11, syntaxin 11
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8676
neXtProt AC: NX_O75558

Human Synonyms: FHL4, HLH4, HPLH4

Human Chr (Location): 6q24.2; chr6:144140051-144191939 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human STX11

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a knock-out allele exhibit defective CTL degranulation and symptoms of hemophagocytic lymphohistiocytosis following infection with LMCV.
 
Human Diseases Modeled in Mice Using Stx11 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Stx11 interacts with 159 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cytotoxic T cell degranulation, intracellular protein transport, ...
Component cell, endomembrane system, ...
Function SNAP receptor activity, SNARE binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (5)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stx11    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000039232 (Evidence)
Entrez Gene 74732 (Evidence)
UniGene 248648
DFCI TC1649825, TC1583457
DoTS DT.97347971, DT.40137368, DT.101371217
NIA Mouse Gene Index U041115
Consensus CDS Project CCDS48500.1
International Mouse Phenotyping Consortium Status Stx11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039232 Ensembl Gene Model | MGI Sequence Detail 24277 C57BL/6J ±  kb
transcript ENSMUST00000163425 Ensembl | MGI Sequence Detail 2261 Not Applicable 
polypeptide ENSMUSP00000132758 Ensembl | MGI Sequence Detail 287 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015786 syntaxin-11
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194197 Kogl T, et al., Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease. Blood. 2013 Jan 24;121(4):604-13
All references(32)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory