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Stx11 Gene Detail
Summary
  • Symbol
    Stx11
  • Name
    syntaxin 11
  • Synonyms
    5830405C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921982
    NCBI Gene: 74732
Location & Maps
more
  • Sequence Map
    Chr10:12939983-12964259 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24277 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STX11, syntaxin 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STX11, syntaxin 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FHL4, HLH4, HPLH4
  • Links
    NCBI Gene ID: 8676
    neXtProt AC: NX_O75558

  • Chr Location
    6q24.2; chr6:144140051-144191939 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2792
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: STX11
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Stx11 mouse models; 1 with human STX11 associations

Human Disease Mouse Models
       Hemophagocytic Lymphohistiocytosis, Familial, 4; FHL4   OMIM: 603552 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit defective CTL degranulation and symptoms of hemophagocytic lymphohistiocytosis following infection with LMCV.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039232 Ensembl Gene Model | MGI Sequence Detail 24277 C57BL/6J ±  kb
transcript ENSMUST00000163425 Ensembl | MGI Sequence Detail 2261 Not Applicable  
polypeptide ENSMUSP00000132758 Ensembl | MGI Sequence Detail 287 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    260 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:221376 Sepulveda FE, et al., A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice. Blood. 2015 Feb 26;125(9):1427-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory