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Stx11 Gene Detail
Summary
  • Symbol
    Stx11
  • Name
    syntaxin 11
  • Synonyms
    5830405C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921982
    NCBI Gene: 74732
  • Gene Overview
    MyGene.info: STX11
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:12939983-12964498 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24516 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 4.54 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    STX11, syntaxin 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STX11, syntaxin 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FHL4, HLH4, HPLH4
  • Links
    NCBI Gene ID: 8676
    neXtProt AC: NX_O75558
    UniProt: O75558

  • Chr Location
    6q24.2; chr6:144140044-144191939 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2792
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STX11
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Stx11 mouse models; 1 with human STX11 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defective CTL degranulation and symptoms of hemophagocytic lymphohistiocytosis following infection with LMCV.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74732 NCBI Gene Model | MGI Sequence Detail 24516 C57BL/6J ±  kb
    transcript NM_029075 RefSeq | MGI Sequence Detail 2396 C57BL/6  
    polypeptide Q9D3G5 UniProt | EBI | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      257 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:232799 Sepulveda FE, et al., Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice. Blood. 2016 Apr 28;127(17):2113-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory