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Stx11
Gene Detail
 Symbol
Name
ID
Stx11
syntaxin 11
MGI:1921982
Synonyms 5830405C08Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
4.54 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:12939983-12964259 bp, - strand
From NCBI annotation of GRCm38

  24277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: syntaxin
Gene Tree: Stx11

Human
homologs
Human Homolog STX11, syntaxin 11
NCBI Gene ID 8676
neXtProt AC  NX_O75558
Human Synonyms  FHL4, HLH4, HPLH4
Human Chr (Location)  6q24.2; chr6:144150440-144191939 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human STX11
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit defective CTL degranulation and symptoms of hemophagocytic lymphohistiocytosis following infection with LMCV.
 
Human Diseases Modeled Using Mouse Stx11 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cytotoxic T cell degranulation, intracellular protein transport, ...
Component cell, Golgi apparatus, ...
Function SNAP receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (5)    Images (6)
Theiler Stages: 23
Assay TypeResults
RNA in situ 13
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000039232 (Evidence)
Entrez Gene74732 (Evidence)
UniGene248648
DFCITC1583457, TC1649825
DoTSDT.101371217, DT.40137368, DT.97347971
NIA Mouse Gene IndexU041115
Consensus CDS ProjectCCDS48500.1
International Mouse Knockout Project StatusStx11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74732 NCBI Gene Model | MGI Sequence Detail 24277 C57BL/6J ±  kb
transcript NM_029075 RefSeq | MGI Sequence Detail 2396 C57BL/6 
polypeptide Q9D3G5 UniProt | EBI | MGI Sequence Detail 287 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015786 syntaxin-11
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194197 Kogl T, et al., Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease. Blood. 2013 Jan 24;121(4):604-13
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory