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Pomk
Gene Detail
 Symbol
Name
ID
Pomk
protein-O-mannose kinase
MGI:1921903
Synonyms 4930444A02Rik, Sgk196
Feature Type protein coding gene
Genetic Map
Chromosome 8
14.25 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:25980604-25994121 bp, - strand
From NCBI annotation of GRCm38

  13518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pomk

Human
homologs
Human Homolog POMK, protein-O-mannose kinase
NCBI Gene ID 84197
neXtProt AC  NX_Q9H5K3
Human Synonyms  MDDGA12, SGK196
Human Chr (Location)  8p11.21; chr8:43093506-43123180 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human POMK
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(20) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap insertion show hydrocephaly and cerebellar dysplasia. Mice also show learning defects, impaired motor strength and decreased sensitivity to pain.
 
Interactions
Pomk interacts with 243 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process brain development, carbohydrate phosphorylation, ...
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function 1-phosphatidylinositol-3-phosphate 4-kinase activity, 1-phosphatidylinositol-5-kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000037251 (Evidence)
Entrez Gene74653 (Evidence)
UniGene17631
DFCITC1575285, TC1595080, TC1726380
DoTSDT.484896, DT.91346177, DT.97405047
NIA Mouse Gene IndexU029675
EC2.7.1.-
Consensus CDS ProjectCCDS22204.1
International Mouse Knockout Project StatusPomk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74653 NCBI Gene Model | MGI Sequence Detail 13518 C57BL/6J ±  kb
transcript NM_029037 RefSeq | MGI Sequence Detail 3601 C57BL/6 
polypeptide Q3TUA9 UniProt | EBI | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000014791 protein kinase-like protein SgK196
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200065 Yoshida-Moriguchi T, et al., SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Science. 2013 Aug 23;341(6148):896-9
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory