4930444A02Rik
Gene Detail

Symbol Name ID

4930444A02Rik RIKEN cDNA 4930444A02 gene MGI:1921903

Feature Type

protein coding gene

Genetic Map

Chromosome 8

14.25 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:25980604-25994121 bp, - strand From NCBI annotation of GRCm38   13518 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12580  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: 4930444A02Rik

Human homologs

Human Homolog		SGK196, protein kinase-like protein SgK196
NCBI Gene ID		84197
neXtProt AC		NX_Q9H5K3
Human Chr (Location)		8p11.21; chr8:42948657-42978323 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(1) Gene trapped(20)
 

Mice homozygous for a gene trap insertion show hydrocephaly and cerebellar dysplasia. Mice also show learning defects, impaired motor strength and decreased sensitivity to pain.

 
Human Diseases Modeled Using Mouse 4930444A02Rik (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	brain development, learning or memory, ...
Component	integral to membrane, membrane
Function	ATP binding, nucleotide binding, ...

External Resources: FuncBase

Expression

cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(36)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000037251 (Evidence)
Entrez Gene	74653 (Evidence)
UniGene	17631
DFCI	TC1575285, TC1595080, TC1726380
DoTS	DT.484896, DT.91346177, DT.97405047
NIA Mouse Gene Index	U029675
Consensus CDS Project	CCDS22204.1
International Mouse Knockout Project Status	4930444A02Rik

Sequences

Length	Strain/Species
genomic	74653	NCBI Gene Model | MGI Sequence Detail	13518	C57BL/6J
transcript	NM_029037	RefSeq | MGI Sequence Detail	3601	C57BL/6
polypeptide	Q3TUA9	UniProt | EBI | MGI Sequence Detail	349	Not Applicable

All sequences(35) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000014791	protein kinase-like protein SgK196

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All references(29)