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Tnks2 Gene Detail
Summary
  • Symbol
    Tnks2
  • Name
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  • Synonyms
    5430432P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921743
    NCBI Gene: 74493
  • Gene Overview
    MyGene.info: TNKS2
Location & Maps
more
  • Sequence Map
    Chr19:36834232-36893477 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59246 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 31.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNKS2, tankyrase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNKS2, tankyrase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARTD6, PARP-5b, PARP5B, PARP-5c, PARP5C, pART6, TANK2, TNKL
  • Links
    NCBI Gene ID: 80351
    neXtProt AC: NX_Q9H2K2

  • Chr Location
    10q23.3; chr10:91798394-91865475 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable but display decreased body weight and abnormal adipocyte glucose uptake in response to insulin stimulation. Mice homozygous for a different null allele show partial postnatal lethality as well as decreased body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035920 VEGA Gene Model | MGI Sequence Detail 59246 C57BL/6J ±  kb
transcript OTTMUST00000092127 VEGA | MGI Sequence Detail 6481 Not Applicable  
polypeptide OTTMUSP00000050843 VEGA | MGI Sequence Detail 1166 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    239 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 7
Other
Accession IDs
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MGI:2147446, MGI:2147590
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:178917 Levaot N, et al., Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism. Cell. 2011 Dec 9;147(6):1324-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory