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Tnks2 Gene Detail
Summary
  • Symbol
    Tnks2
  • Name
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  • Synonyms
    5430432P15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921743
    NCBI Gene: 74493
  • Gene Overview
    MyGene.info: TNKS2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:36834232-36893477 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 31.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    239 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921743
protein coding gene Chr19:36834230-36893477 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025074
protein coding gene Chr19:35741048-35799968 (+)
A/J MGP_AJ_G0025050
protein coding gene Chr19:34031239-34091085 (+)
AKR/J MGP_AKRJ_G0025018
protein coding gene Chr19:35184182-35244836 (+)
BALB/cJ MGP_BALBcJ_G0025048
protein coding gene Chr19:34114262-34173349 (+)
C3H/HeJ MGP_C3HHeJ_G0024807
protein coding gene Chr19:35240358-35303882 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025489
protein coding gene Chr19:36773662-36837064 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022907
protein coding gene Chr19:33399725-33456643 (+)
CAST/EiJ MGP_CASTEiJ_G0024274
protein coding gene Chr19:35070675-35135047 (+)
CBA/J MGP_CBAJ_G0024784
protein coding gene Chr19:38525110-38584329 (+)
DBA/2J MGP_DBA2J_G0024916
protein coding gene Chr19:33888670-33948107 (+)
FVB/NJ MGP_FVBNJ_G0024877
protein coding gene Chr19:33697077-33756369 (+)
LP/J MGP_LPJ_G0025002
protein coding gene Chr19:35838436-35906704 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024908
protein coding gene Chr19:38341163-38407210 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025547
protein coding gene Chr19:35270875-35331992 (+)
PWK/PhJ MGP_PWKPhJ_G0024026
protein coding gene Chr19:33715699-33777394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023826
protein coding gene Chr19:34096561-34157619 (+)
WSB/EiJ MGP_WSBEiJ_G0024341
protein coding gene Chr19:35363143-35424960 (+)



Homology
more
  • Human Ortholog
    TNKS2, tankyrase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNKS2, tankyrase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARTD6, PARP-5b, PARP5B, PARP-5c, PARP5C, pART6, TANK2, TNKL
  • Links
    NCBI Gene ID: 80351
    neXtProt AC: NX_Q9H2K2
    UniProt: Q9H2K2

  • Chr Location
    10q23.32; chr10:91798394-91865475 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable but display decreased body weight and abnormal adipocyte glucose uptake in response to insulin stimulation. Mice homozygous for a different null allele show partial postnatal lethality as well as decreased body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024811 Ensembl Gene Model | MGI Sequence Detail 59246 C57BL/6J ±  kb
    transcript ENSMUST00000025729 Ensembl | MGI Sequence Detail 6481 Not Applicable  
    polypeptide ENSMUSP00000025729 Ensembl | MGI Sequence Detail 1166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147446, MGI:2147590
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:266195 Ye P, et al., Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death. PLoS Genet. 2018 Sep;14(9):e1007697

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory