Samd4 MGI Mouse Gene Detail - MGI:1921730 - sterile alpha motif domain containing 4

Symbol

Samd4
Name

sterile alpha motif domain containing 4
Synonyms

1700024G08Rik, 1700111L17Rik, 4933436G17Rik, Smaug, sunk

Feature Type

protein coding gene
IDs

MGI:1921730
NCBI Gene: 74480
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr14:47120414-47343274 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 24.41 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

6109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921730	protein coding gene	Chr14:47120311-47343274 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021217	protein coding gene	Chr14:40575996-40821535 (+)
A/J	MGP_AJ_G0021164	protein coding gene	Chr14:39366788-39595799 (+)
AKR/J	MGP_AKRJ_G0021142	protein coding gene	Chr14:40896755-41129485 (+)
BALB/cJ	MGP_BALBcJ_G0021168	protein coding gene	Chr14:39414293-39646842 (+)
C3H/HeJ	MGP_C3HHeJ_G0020951	protein coding gene	Chr14:40676393-40921341 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021602	protein coding gene	Chr14:42329698-42569821 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019161	protein coding gene	Chr14:38730492-38954410 (+)
CAST/EiJ	MGP_CASTEiJ_G0020476	protein coding gene	Chr14:37808347-38044614 (+)
CBA/J	MGP_CBAJ_G0020917	protein coding gene	Chr14:43658644-43908379 (+)
DBA/2J	MGP_DBA2J_G0021040	protein coding gene	Chr14:39264990-39492503 (+)
FVB/NJ	MGP_FVBNJ_G0021025	protein coding gene	Chr14:38995737-39224529 (+)
LP/J	MGP_LPJ_G0021110	protein coding gene	Chr14:40869310-41104915 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021050	protein coding gene	Chr14:43028780-43267092 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021635	protein coding gene	Chr14:40434537-40679257 (+)
PWK/PhJ	MGP_PWKPhJ_G0020225	protein coding gene	Chr14:36138757-36366294 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020049	protein coding gene	Chr14:36564044-36802201 (+)
WSB/EiJ	MGP_WSBEiJ_G0020532	protein coding gene	Chr14:40544797-40787701 (+)

Human Ortholog

SAMD4A, sterile alpha motif domain containing 4A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SAMD4A, sterile alpha motif domain containing 4A
Synonyms

SAMD4, SMAUG, SMAUG1, SMG, SMGA
Links

HGNC:23023

NCBI Gene ID: 23034

UniProt: Q9UPU9
Chr Location

14q22.2; chr14:54565316-54793315 (+) GRCh38

MGI Vertebrate Homology

Samd4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SAMD4A
Gene Tree

Samd4

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Phenotype Summary

37 phenotypes from 2 alleles in 2 genetic backgrounds
4 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Samd4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit leaness, myopathy and altered glucose metabolism. Mice homozygous for a spontaneous mutation exhibit kyphosis, abnormal gait, and decreased cortical bone thickness.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

9
cDNA Data

17
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase samd4a

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All Sequences

84
RefSeq

20
UniProt

4
CCDS

CCDS26982.1, CCDS26983.1, CCDS49468.1, CCDS79301.1

Ensembl

ENSMUSG00000021838 (Evidence)
NCBI Gene

74480

			Length	Strain/Species	Flank
genomic	74480	NCBI Gene Model \| MGI Sequence Detail	222861	C57BL/6J	± kb
transcript	NM_001037221	RefSeq \| MGI Sequence Detail	7120	C57BL/6
polypeptide	Q8CBY1	UniProt \| EBI \| MGI Sequence Detail	711	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032110 protein Smaug homolog 1

(term hierarchy)
InterPro Domains

IPR037634 Protein Smaug, SAM domain

IPR037093 Smaug, PHAT domain superfamily

IPR050897 SMAUG/VTS1 RNA-binding

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

Q8CBY1 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 19

cDNA 17

Primer pair 2

Microarray probesets 5

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MGI:1916635, MGI:1925725, MGI:3624555

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Samd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125240	Chr14:47120388-47120393 (+)	-23 bp
Tssr125241	Chr14:47120415-47120430 (+)	9 bp
Tssr125242	Chr14:47120451-47120456 (+)	40 bp
Tssr4382	Chr14:47121487-47121507 (+)	1,083 bp
Tssr125243	Chr14:47122033-47122042 (+)	1,624 bp
Tssr125244	Chr14:47126787-47126792 (+)	6,376 bp
Tssr125245	Chr14:47126818-47126835 (+)	6,413 bp
Tssr125246	Chr14:47136883-47136902 (+)	16,479 bp
Tssr125247	Chr14:47238793-47238800 (+)	118,383 bp
Tssr125248	Chr14:47238811-47238834 (+)	118,409 bp
Tssr125249	Chr14:47238836-47238850 (+)	118,429 bp
Tssr125250	Chr14:47300327-47300331 (+)	179,915 bp
Tssr4383	Chr14:47302453-47302460 (+)	182,043 bp
Tssr125251	Chr14:47303874-47303896 (+)	183,471 bp
Tssr125252	Chr14:47306395-47306405 (+)	185,986 bp
Tssr125253	Chr14:47306419-47306440 (+)	186,016 bp
Tssr125254	Chr14:47306450-47306489 (+)	186,056 bp
Tssr125255	Chr14:47306497-47306506 (+)	186,088 bp
Tssr125256	Chr14:47324982-47324987 (+)	204,571 bp
Tssr4384	Chr14:47335205-47335209 (+)	214,793 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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