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Samd4 Gene Detail
Summary
  • Symbol
    Samd4
  • Name
    sterile alpha motif domain containing 4
  • Synonyms
    1700024G08Rik, 1700111L17Rik, 4933436G17Rik, Smaug, sunk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921730
    NCBI Gene: 74480
  • Gene Overview
    MyGene.info: SAMD4A
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:46882965-47105817 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 24.41 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2043 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921730
protein coding gene Chr14:46882854-47105817 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021217
protein coding gene Chr14:40575996-40821535 (+)
A/J MGP_AJ_G0021164
protein coding gene Chr14:39366788-39595799 (+)
AKR/J MGP_AKRJ_G0021142
protein coding gene Chr14:40896755-41129485 (+)
BALB/cJ MGP_BALBcJ_G0021168
protein coding gene Chr14:39414293-39646842 (+)
C3H/HeJ MGP_C3HHeJ_G0020951
protein coding gene Chr14:40676393-40921341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021602
protein coding gene Chr14:42329698-42569821 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019161
protein coding gene Chr14:38730492-38954410 (+)
CAST/EiJ MGP_CASTEiJ_G0020476
protein coding gene Chr14:37808347-38044614 (+)
CBA/J MGP_CBAJ_G0020917
protein coding gene Chr14:43658644-43908379 (+)
DBA/2J MGP_DBA2J_G0021040
protein coding gene Chr14:39264990-39492503 (+)
FVB/NJ MGP_FVBNJ_G0021025
protein coding gene Chr14:38995737-39224529 (+)
LP/J MGP_LPJ_G0021110
protein coding gene Chr14:40869310-41104915 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021050
protein coding gene Chr14:43028780-43267092 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021635
protein coding gene Chr14:40434537-40679257 (+)
PWK/PhJ MGP_PWKPhJ_G0020225
protein coding gene Chr14:36138757-36366294 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020049
protein coding gene Chr14:36564044-36802201 (+)
WSB/EiJ MGP_WSBEiJ_G0020532
protein coding gene Chr14:40544797-40787701 (+)



Homology
more
  • Human Ortholog
    SAMD4A, sterile alpha motif domain containing 4A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SAMD4A, sterile alpha motif domain containing 4A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SAMD4, SMAUG, SMAUG1, SMG, SMGA
  • Links
    NCBI Gene ID: 23034
    neXtProt AC: NX_Q9UPU9
    UniProt: Q9UPU9

  • Chr Location
    14q22.2; chr14:54567612-54793315 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 19167
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SAMD4A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    4 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit leaness, myopathy and altered glucose metabolism. Mice homozygous for a spontaneous mutation exhibit kyphosis, abnormal gait, and decreased cortical bone thickness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74480 NCBI Gene Model | MGI Sequence Detail 222853 C57BL/6J ±  kb
    transcript NM_001037221 RefSeq | MGI Sequence Detail 7120 C57BL/6  
    polypeptide Q8CBY1 UniProt | EBI | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916635, MGI:1925725, MGI:3624555
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:227840 Amadei G, et al., A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. J Neurosci. 2015 Nov 25;35(47):15666-81

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory