Samd4 MGI Mouse Gene Detail - MGI:1921730 - sterile alpha motif domain containing 4

Symbol

Samd4
Name

sterile alpha motif domain containing 4
Synonyms

1700024G08Rik, 1700111L17Rik, 4933436G17Rik, Smaug, sunk

Feature Type

protein coding gene
IDs

MGI:1921730
NCBI Gene: 74480
Gene Overview

MyGene.info: SAMD4A
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr14:46882965-47105817 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 24.41 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

2043 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921730	protein coding gene	Chr14:46882854-47105817 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021217	protein coding gene	Chr14:40575996-40821535 (+)
A/J	MGP_AJ_G0021164	protein coding gene	Chr14:39366788-39595799 (+)
AKR/J	MGP_AKRJ_G0021142	protein coding gene	Chr14:40896755-41129485 (+)
BALB/cJ	MGP_BALBcJ_G0021168	protein coding gene	Chr14:39414293-39646842 (+)
C3H/HeJ	MGP_C3HHeJ_G0020951	protein coding gene	Chr14:40676393-40921341 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021602	protein coding gene	Chr14:42329698-42569821 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019161	protein coding gene	Chr14:38730492-38954410 (+)
CAST/EiJ	MGP_CASTEiJ_G0020476	protein coding gene	Chr14:37808347-38044614 (+)
CBA/J	MGP_CBAJ_G0020917	protein coding gene	Chr14:43658644-43908379 (+)
DBA/2J	MGP_DBA2J_G0021040	protein coding gene	Chr14:39264990-39492503 (+)
FVB/NJ	MGP_FVBNJ_G0021025	protein coding gene	Chr14:38995737-39224529 (+)
LP/J	MGP_LPJ_G0021110	protein coding gene	Chr14:40869310-41104915 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021050	protein coding gene	Chr14:43028780-43267092 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021635	protein coding gene	Chr14:40434537-40679257 (+)
PWK/PhJ	MGP_PWKPhJ_G0020225	protein coding gene	Chr14:36138757-36366294 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020049	protein coding gene	Chr14:36564044-36802201 (+)
WSB/EiJ	MGP_WSBEiJ_G0020532	protein coding gene	Chr14:40544797-40787701 (+)

Human Ortholog

SAMD4A, sterile alpha motif domain containing 4A

Vertebrate Orthologs

10

Human Ortholog

SAMD4A, sterile alpha motif domain containing 4A
Orthology source: HomoloGene, HGNC
Synonyms

SAMD4, SMAUG, SMAUG1, SMG, SMGA
Links

HGNC:23023

NCBI Gene ID: 23034

neXtProt AC: NX_Q9UPU9

UniProt: Q9UPU9
Chr Location

14q22.2; chr14:54567612-54793315 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 19167
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SAMD4A
Gene Tree

Samd4

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Phenotype Summary

37 phenotypes from 2 alleles in 2 genetic backgrounds
4 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

2
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Samd4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit leaness, myopathy and altered glucose metabolism. Mice homozygous for a spontaneous mutation exhibit kyphosis, abnormal gait, and decreased cortical bone thickness.

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All GO Annotations

17
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

10
Tissues

9
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Samd4 interacts with 451 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

80
RefSeq

16
UniProt

4
CCDS

CCDS26982.1, CCDS26983.1, CCDS49468.1, CCDS79301.1

Ensembl

ENSMUSG00000021838 (Evidence)
NCBI Gene

74480

			Length	Strain/Species	Flank
genomic	74480	NCBI Gene Model \| MGI Sequence Detail	222853	C57BL/6J	± kb
transcript	NM_001037221	RefSeq \| MGI Sequence Detail	7120	C57BL/6
polypeptide	Q8CBY1	UniProt \| EBI \| MGI Sequence Detail	711	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032110 protein Smaug homolog 1

(term hierarchy)
InterPro Domains

IPR037634 Protein Smaug, SAM domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 5

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MGI:1916635, MGI:1925725, MGI:3624555

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:227840 Amadei G, et al., A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. J Neurosci. 2015 Nov 25;35(47):15666-81

TSS for Samd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125240	Chr14:46882931-46882936 (+)	-31 bp
Tssr125241	Chr14:46882958-46882973 (+)	1 bp
Tssr125242	Chr14:46882994-46882999 (+)	32 bp
Tssr4382	Chr14:46884030-46884050 (+)	1,075 bp
Tssr125243	Chr14:46884576-46884585 (+)	1,616 bp
Tssr125247	Chr14:47001336-47001343 (+)	118,375 bp
Tssr125248	Chr14:47001354-47001377 (+)	118,401 bp
Tssr125249	Chr14:47001379-47001393 (+)	118,421 bp
Tssr125252	Chr14:47068938-47068948 (+)	185,978 bp
Tssr125253	Chr14:47068962-47068983 (+)	186,008 bp
Tssr125254	Chr14:47068993-47069032 (+)	186,048 bp
Tssr125255	Chr14:47069040-47069049 (+)	186,080 bp
Tssr125256	Chr14:47087525-47087530 (+)	204,563 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14