About   Help   FAQ
Clec16a Gene Detail
Summary
  • Symbol
    Clec16a
  • Name
    C-type lectin domain family 16, member A
  • Synonyms
    4932416N17Rik, curt, mKIAA0350
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921624
    NCBI Gene: 74374
  • Gene Overview
    MyGene.info: CLEC16A
Location & Maps
more
  • Sequence Map
    Chr16:10545364-10744878 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      199515 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 5.68 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLEC16A, C-type lectin domain family 16 member A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLEC16A, C-type lectin domain family 16 member A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Gop-1, KIAA0350
  • Links
    NCBI Gene ID: 23274
    neXtProt AC: NX_Q2KHT3

  • Chr Location
    16p13.13; chr16:10944488-11193278 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation have a curved tail, small body size, squinting eyes, crooked digits that curve outward, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023673 VEGA Gene Model | MGI Sequence Detail 199515 C57BL/6J ±  kb
transcript OTTMUST00000057779 VEGA | MGI Sequence Detail 6213 Not Applicable  
polypeptide OTTMUSP00000027920 VEGA | MGI Sequence Detail 1034 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1059 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005561 protein CLEC16A
  • InterPro Domains
    IPR019155 Uncharacterised protein family FPL
Molecular
Reagents
less
  • All nucleic 54
    cDNA 54

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146669, MGI:4868747
References
more
  • Summaries
    All 32
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229746 Schuster C, et al., The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. Immunity. 2015 May 19;42(5):942-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory