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Clec16a Gene Detail
Summary
  • Symbol
    Clec16a
  • Name
    C-type lectin domain family 16, member A
  • Synonyms
    4932416N17Rik, curt, mKIAA0350
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921624
    NCBI Gene: 74374
  • Gene Overview
    MyGene.info: CLEC16A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10545339-10744878 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 5.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1059 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921624
protein coding gene Chr16:10545339-10744878 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022510
protein coding gene Chr16:7353500-7567101 (+)
A/J MGP_AJ_G0022472
protein coding gene Chr16:6952968-7154871 (+)
AKR/J MGP_AKRJ_G0022448
protein coding gene Chr16:7272437-7475174 (+)
BALB/cJ MGP_BALBcJ_G0022476
protein coding gene Chr16:7085737-7285153 (+)
C3H/HeJ MGP_C3HHeJ_G0022243
protein coding gene Chr16:7348776-7557750 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022925
protein coding gene Chr16:7505133-7719755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020446
protein coding gene Chr16:7094325-7300016 (+)
CAST/EiJ MGP_CASTEiJ_G0021770
protein coding gene Chr16:7367577-7577401 (+)
CBA/J MGP_CBAJ_G0022212
protein coding gene Chr16:7831312-8056279 (+)
DBA/2J MGP_DBA2J_G0022343
protein coding gene Chr16:6959278-7156866 (+)
FVB/NJ MGP_FVBNJ_G0022319
protein coding gene Chr16:6942463-7139127 (+)
LP/J MGP_LPJ_G0022411
protein coding gene Chr16:7311995-7521472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022341
protein coding gene Chr16:7569720-7777655 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022938
protein coding gene Chr16:7219483-7424078 (+)
PWK/PhJ MGP_PWKPhJ_G0021510
protein coding gene Chr16:7163696-7366028 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021340
protein coding gene Chr16:7283832-7485543 (+)
WSB/EiJ MGP_WSBEiJ_G0021818
protein coding gene Chr16:7294892-7501720 (+)



Homology
more
  • Human Ortholog
    CLEC16A, C-type lectin domain containing 16A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLEC16A, C-type lectin domain containing 16A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gop-1, KIAA0350
  • Links
    NCBI Gene ID: 23274
    neXtProt AC: NX_Q2KHT3
    UniProt: Q2KHT3

  • Chr Location
    16p13.13; chr16:10944488-11193272 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation have a curved tail, small body size, squinting eyes, crooked digits that curve outward, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 74374 NCBI Gene Model | MGI Sequence Detail 199540 C57BL/6J ±  kb
transcript NM_177562 RefSeq | MGI Sequence Detail 6262 C57BL/6  
polypeptide Q80U30 UniProt | EBI | MGI Sequence Detail 1036 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146669, MGI:4868747
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:257843 Pearson G, et al., Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates beta-Cell Mitophagy. Diabetes. 2018 Feb;67(2):265-277

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory