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Ulk4
Gene Detail
Symbol

Name
ID
Ulk4
unc-51-like kinase 4
MGI:1921622
Synonyms
4932415A06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.19 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:120960268-121277197 bp, - strand
From VEGA annotation of GRCm38

  316930 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41205  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ULK4
Gene Tree: Ulk4

Human
homologs
ULK4, unc-51 like kinase 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 54986
neXtProt AC: NX_Q96C45

Human Synonyms: FAM7C1, REC01035

Human Chr (Location): 3p22.1; chr3:41239987-41962887 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation exhibit reduced body size, hydrocephalus and dilation of brain ventricles and otitis media with most mice dieing before four months of age. Mice homozygous for a different knock-out allele exhibit partial agenesis of the corpus callosum.
 
Interactions
Ulk4 interacts with 332 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cilium morphogenesis, corpus callosum development, ...
Component cellular_component
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (20)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
Western blot 8
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ulk4    NEW 
Molecular
reagents
All nucleic(50) cDNA(50)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036158 (Evidence)
Ensembl Gene Model ENSMUSG00000040936 (Evidence)
Entrez Gene 209012 (Evidence)
UniGene 371804
EC 2.7.11.1
Consensus CDS Project CCDS52967.1
International Mouse Phenotyping Consortium Status Ulk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036158 VEGA Gene Model | MGI Sequence Detail 316930 C57BL/6J ±  kb
transcript OTTMUST00000092956 VEGA | MGI Sequence Detail 4103 Not Applicable 
polypeptide OTTMUSP00000051478 VEGA | MGI Sequence Detail 1275 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(2571 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2579)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000017080 serine/threonine-protein kinase ULK4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211886 Lang B, et al., Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility. J Cell Sci. 2014 Feb 1;127(Pt 3):630-40
All references(28)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory