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Slc6a19 Gene Detail
Summary
  • Symbol
    Slc6a19
  • Name
    solute carrier family 6 (neurotransmitter transporter), member 19
  • Synonyms
    4632401C08Rik, B0AT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921588
    NCBI Gene: 74338
  • Gene Overview
    MyGene.info: SLC6A19
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73679745-73700695 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.14 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921588
protein coding gene Chr13:73679745-73704865 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020750
protein coding gene Chr13:74151444-74177759 (-)
A/J MGP_AJ_G0020706
protein coding gene Chr13:71502360-71527468 (-)
AKR/J MGP_AKRJ_G0020680
protein coding gene Chr13:73749391-73776609 (-)
BALB/cJ MGP_BALBcJ_G0020703
protein coding gene Chr13:71993780-72019309 (-)
C3H/HeJ MGP_C3HHeJ_G0020497
protein coding gene Chr13:73431309-73456973 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021140
protein coding gene Chr13:76619558-76646025 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018707
protein coding gene Chr13:68321767-68348116 (-)
CAST/EiJ MGP_CASTEiJ_G0020014
protein coding gene Chr13:72511651-72537231 (-)
CBA/J MGP_CBAJ_G0020456
protein coding gene Chr13:79469453-79497395 (-)
DBA/2J MGP_DBA2J_G0020581
protein coding gene Chr13:71323163-71348342 (-)
FVB/NJ MGP_FVBNJ_G0020561
protein coding gene Chr13:70346063-70372661 (-)
LP/J MGP_LPJ_G0020654
protein coding gene Chr13:74391475-74417333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020589
protein coding gene Chr13:77897082-77923244 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021179
protein coding gene Chr13:73058735-73085147 (-)
PWK/PhJ MGP_PWKPhJ_G0019768
protein coding gene Chr13:70057818-70083298 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019591
protein coding gene Chr13:69526156-69557731 (-)
WSB/EiJ MGP_WSBEiJ_G0020072
protein coding gene Chr13:73608232-73635516 (-)



Homology
more
  • Human Ortholog
    SLC6A19, solute carrier family 6 member 19
  • Vertebrate Orthologs
    12
  • Human Ortholog
    SLC6A19, solute carrier family 6 member 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B0AT1, HND
  • Links
    NCBI Gene ID: 340024
    neXtProt AC: NX_Q695T7
    UniProt: Q695T7

  • Chr Location
    5p15.33; chr5:1201595-1225117 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc6a19 mouse models; 1 with human SLC6A19 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight and impaired amino acid absorption and excretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74338 NCBI Gene Model | MGI Sequence Detail 20951 C57BL/6J ±  kb
    transcript NM_028878 RefSeq | MGI Sequence Detail 3948 C57BL/6  
    polypeptide Q9D687 UniProt | EBI | MGI Sequence Detail 634 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015185 sodium-dependent neutral amino acid transporter B(0)AT1
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR002438 Sodium:neurotransmitter symporter, orphan
      IPR037272 Sodium:neurotransmitter symporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:257334 Fairweather SJ, et al., Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin. J Biol Chem. 2015 Oct 2;290(40):24308-25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory