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Mettl23 Gene Detail
Summary
  • Symbol
    Mettl23
  • Name
    methyltransferase like 23
  • Synonyms
    1110005A03Rik, 1500035B17Rik, 4933424L15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921569
    NCBI Gene: 74319
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116843515-116849740 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.49 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921569
protein coding gene Chr11:116843278-116854263 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019441
protein coding gene Chr11:121006125-121017114 (+)
A/J MGP_AJ_G0019409
protein coding gene Chr11:115668761-115673619 (+)
AKR/J MGP_AKRJ_G0019379
protein coding gene Chr11:119204311-119209123 (+)
BALB/cJ MGP_BALBcJ_G0019384
protein coding gene Chr11:116062138-116068354 (+)
C3H/HeJ MGP_C3HHeJ_G0019190
protein coding gene Chr11:119472600-119478801 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019833
protein coding gene Chr11:124733729-124745419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017456
protein coding gene Chr11:112681214-112692203 (+)
CAST/EiJ MGP_CASTEiJ_G0018744
protein coding gene Chr11:120892263-120903263 (+)
CBA/J MGP_CBAJ_G0019161
protein coding gene Chr11:129593206-129599408 (+)
DBA/2J MGP_DBA2J_G0019273
protein coding gene Chr11:115091195-115096028 (+)
FVB/NJ MGP_FVBNJ_G0019265
protein coding gene Chr11:114650264-114661844 (+)
LP/J MGP_LPJ_G0019343
protein coding gene Chr11:121352774-121363727 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019298
protein coding gene Chr11:128648124-128659771 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019872
protein coding gene Chr11:119835415-119847288 (+)
PWK/PhJ MGP_PWKPhJ_G0018509
protein coding gene Chr11:116426335-116438353 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018302
protein coding gene Chr11:119569073-119580109 (+)
WSB/EiJ MGP_WSBEiJ_G0018796
protein coding gene Chr11:119779624-119790607 (+)



Homology
more
  • Human Ortholog
    METTL23, methyltransferase like 23
  • Vertebrate Orthologs
    10
  • Human Ortholog
    METTL23, methyltransferase like 23
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf95, MRT44
  • Links
    NCBI Gene ID: 124512
    neXtProt AC: NX_Q86XA0
    UniProt: Q86XA0

  • Chr Location
    17q25.1; chr17:76725874-76733881 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human METTL23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74319 NCBI Gene Model | MGI Sequence Detail 6226 C57BL/6J ±  kb
transcript NM_028865 RefSeq | MGI Sequence Detail 1055 C57BL/6  
polypeptide A2AA28 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1918365, MGI:1923742
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:254851 Hatanaka Y, et al., Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Cell Rep. 2017 Sep 19;20(12):2756-2765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory