About   Help   FAQ
Mettl23 Gene Detail
Summary
  • Symbol
    Mettl23
  • Name
    methyltransferase like 23
  • Synonyms
    1110005A03Rik, 1500035B17Rik, 4933424L15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921569
    NCBI Gene: 74319
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116734341-116740566 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.49 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921569
protein coding gene Chr11:116734104-116745089 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019441
protein coding gene Chr11:121006125-121017114 (+)
A/J MGP_AJ_G0019409
protein coding gene Chr11:115668761-115673619 (+)
AKR/J MGP_AKRJ_G0019379
protein coding gene Chr11:119204311-119209123 (+)
BALB/cJ MGP_BALBcJ_G0019384
protein coding gene Chr11:116062138-116068354 (+)
C3H/HeJ MGP_C3HHeJ_G0019190
protein coding gene Chr11:119472600-119478801 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019833
protein coding gene Chr11:124733729-124745419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017456
protein coding gene Chr11:112681214-112692203 (+)
CAST/EiJ MGP_CASTEiJ_G0018744
protein coding gene Chr11:120892263-120903263 (+)
CBA/J MGP_CBAJ_G0019161
protein coding gene Chr11:129593206-129599408 (+)
DBA/2J MGP_DBA2J_G0019273
protein coding gene Chr11:115091195-115096028 (+)
FVB/NJ MGP_FVBNJ_G0019265
protein coding gene Chr11:114650264-114661844 (+)
LP/J MGP_LPJ_G0019343
protein coding gene Chr11:121352774-121363727 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019298
protein coding gene Chr11:128648124-128659771 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019872
protein coding gene Chr11:119835415-119847288 (+)
PWK/PhJ MGP_PWKPhJ_G0018509
protein coding gene Chr11:116426335-116438353 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018302
protein coding gene Chr11:119569073-119580109 (+)
WSB/EiJ MGP_WSBEiJ_G0018796
protein coding gene Chr11:119779624-119790607 (+)



Homology
more
  • Human Ortholog
    METTL23, methyltransferase 23, arginine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL23, methyltransferase 23, arginine
  • Synonyms
    C17orf95, MRT44
  • Links
    NCBI Gene ID: 124512
    neXtProt AC: NX_Q86XA0
    UniProt: Q86XA0

  • Chr Location
    17q25.1; chr17:76726041-76733936 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Mettl23 mouse models; 1 with human METTL23 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal-tension glaucoma with loss of retinal ganglion cells and optic nerve atrophy. Mice homozygous for a different null allele show partial postnatal lethality, low survivor rate, decreased litter size, and abnormal active DNA demethylation of the paternal genome.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74319 NCBI Gene Model | MGI Sequence Detail 6226 C57BL/6J ±  kb
    transcript NM_028865 RefSeq | MGI Sequence Detail 1055 C57BL/6  
    polypeptide A2AA28 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1918365, MGI:1923742
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:330971 Pan Y, et al., METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma. J Clin Invest. 2022 Nov 1;132(21):e153589

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory