Mettl23^em1Itwa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl23^em1Itwa
• Name: methyltransferase like 23; endonuclease-mediated mutation 1, Takeshi Iwata
• MGI ID: MGI:7388493
• Synonyms: Mettl23^G, Mettl23^KI
• Gene: Mettl23 Location: Chr11:116734341-116740566 bp, + strand Genetic Position: Chr11, 81.49 cM, cytoband E2
• Alliance: Mettl23^em1Itwa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutation (A to G) responsible to the amino acid substitution of glutamic acid to glycine identical to the glaucomatous mutation in the human gene. (J:330971)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl23 Mutation: 20 strains or lines available

References

• Original: J:330971 Pan Y, et al., METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma. J Clin Invest. 2022 Nov 1;132(21):e153589
• All: 1 reference(s)