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Robo4
Gene Detail
 Symbol
Name
ID
Robo4
roundabout homolog 4 (Drosophila)
MGI:1921394
Synonyms 1200012D01Rik, Magic roundabout
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:37401897-37414023 bp, + strand
From VEGA annotation of GRCm38

  12127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10397  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Robo4

Human
homologs
Human Homolog ROBO4, roundabout, axon guidance receptor, homolog 4 (Drosophila)
NCBI Gene ID 54538
neXtProt AC  NX_Q8WZ75
Human Synonyms  ECSM4, MRB
Human Chr (Location)  11q24.2; chr11:124884218-124897952 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization.
 
Interactions
Robo4 interacts with 99 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process angiogenesis, cell differentiation, ...
Component external side of plasma membrane, extracellular vesicular exosome, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (64)    Tissues (35)    Images (14)
Theiler Stages: 12, 15, 16, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 44
In situ reporter (knock in) 20
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016772 (Evidence)
Ensembl Gene ModelENSMUSG00000032125 (Evidence)
Entrez Gene74144 (Evidence)
UniGene485070
DFCITC1575931, TC1595760, TC1615727
DoTSDT.102555900, DT.527366, DT.97374127, DT.97375293, DT.97376524
NIA Mouse Gene IndexU010258
Consensus CDS ProjectCCDS22977.1
International Mouse Knockout Project StatusRobo4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016772 VEGA Gene Model | MGI Sequence Detail 12127 C57BL/6J ±  kb
transcript OTTMUST00000040717 VEGA | MGI Sequence Detail 3878 Not Applicable 
polypeptide OTTMUSP00000018207 VEGA | MGI Sequence Detail 1074 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000014154 roundabout homolog 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208012 Zhang B, et al., Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan 2;124(1):209-21
All references(53)
Other
accession IDs
MGI:2143097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory