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Sash3 Gene Detail
Summary
  • Symbol
    Sash3
  • Name
    SAM and SH3 domain containing 3
  • Synonyms
    1200013B08Rik, SLY1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921381
    NCBI Gene: 74131
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:47235313-47250442 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 25.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921381
protein coding gene ChrX:47235313-47250442 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035688
protein coding gene ChrX:43279496-43294695 (+)
A/J MGP_AJ_G0035671
protein coding gene ChrX:43153923-43170567 (+)
AKR/J MGP_AKRJ_G0035591
protein coding gene ChrX:44333331-44353045 (+)
BALB/cJ MGP_BALBcJ_G0035657
protein coding gene ChrX:42804974-42820106 (+)
C3H/HeJ MGP_C3HHeJ_G0035361
protein coding gene ChrX:43581334-43596442 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036186
protein coding gene ChrX:44310893-44326034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033038
protein coding gene ChrX:40844636-40859907 (+)
CAST/EiJ MGP_CASTEiJ_G0034652
protein coding gene ChrX:31164279-31179434 (+)
CBA/J MGP_CBAJ_G0035335
protein coding gene ChrX:45548003-45563159 (+)
DBA/2J MGP_DBA2J_G0035489
protein coding gene ChrX:43004056-43019258 (+)
FVB/NJ MGP_FVBNJ_G0035438
protein coding gene ChrX:42711104-42726655 (+)
LP/J MGP_LPJ_G0035577
protein coding gene ChrX:43646283-43661407 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035476
protein coding gene ChrX:46962155-46977279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036204
protein coding gene ChrX:43193739-43208868 (+)
PWK/PhJ MGP_PWKPhJ_G0034351
protein coding gene ChrX:30647798-30663067 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034196
protein coding gene ChrX:31950547-31965810 (+)
WSB/EiJ MGP_WSBEiJ_G0034796
protein coding gene ChrX:42816497-42831677 (+)



Homology
more
  • Human Ortholog
    SASH3, SAM and SH3 domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SASH3, SAM and SH3 domain containing 3
  • Synonyms
    753P9, CXorf9, HACS2, IMD102, SH3D6C, SLY
  • Links
    NCBI Gene ID: 54440
    neXtProt AC: NX_O75995
    UniProt: O75995

  • Chr Location
    Xq26.1; chrX:129779949-129795201 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SASH3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a truncation allele exhibit decreased T and B cells, altered B cell physiology and increased length of semi-identical allograft survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74131 NCBI Gene Model | MGI Sequence Detail 15130 C57BL/6J ±  kb
    transcript NM_001313749 RefSeq | MGI Sequence Detail 2695 C57BL/6  
    polypeptide Q8K352 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2148010
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333873 Gruber LC, et al., Knockout of SLy1 decreases double-negative thymocyte proliferation and protects mice from p53-induced tumor formation. Eur J Immunol. 2023 Jan;53(1):e2250017

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory