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Sash3
Gene Detail
 Symbol
Name
ID
Sash3
SAM and SH3 domain containing 3
MGI:1921381
Synonyms 1200013B08Rik, SLY1
Feature Type protein coding gene
Genetic Map
Chromosome X
25.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:48146436-48161565 bp, + strand
From VEGA annotation of GRCm38

  15130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10362  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sash3

Human
homologs
Human Homolog SASH3, SAM and SH3 domain containing 3
NCBI Gene ID 54440
neXtProt AC  NX_O75995
Human Synonyms  753P9, CXorf9, HACS2, SH3D6C, SLY
Human Chr (Location)  Xq26; chrX:129779916-129795201 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Mice homozygous for a truncation allele exhibit decreased T and B cells, altered B cell physiology and increased length of semi-identical allograft survival.
 
Interactions
Sash3 interacts with 183 markers (Mir17, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process homeostasis of number of cells within a tissue, positive regulation of adaptive immune response, ...
Component cytoplasm, nucleus
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (15)    Tissues (2)    Images (10)
Theiler Stages: 23
Assay TypeResults
RNA in situ 15
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017509 (Evidence)
Ensembl Gene ModelENSMUSG00000031101 (Evidence)
Entrez Gene74131 (Evidence)
UniGene276131
DFCITC1579818
DoTSDT.529209
NIA Mouse Gene IndexU019835
Consensus CDS ProjectCCDS40959.1
International Mouse Knockout Project StatusSash3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017509 VEGA Gene Model | MGI Sequence Detail 15130 C57BL/6J ±  kb
transcript OTTMUST00000042517 VEGA | MGI Sequence Detail 2677 Not Applicable 
polypeptide OTTMUSP00000019111 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021090 SAM/SH3 domain-containing
InterPro IPR001452 Src homology-3 domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
InterPro IPR011511 Variant SH3
Protein Ontology PR:000014464 SAM and SH3 domain-containing protein 3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(28)
Other
accession IDs
MGI:2148010

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory