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Sash3 Gene Detail
Summary
  • Symbol
    Sash3
  • Name
    SAM and SH3 domain containing 3
  • Synonyms
    1200013B08Rik, SLY1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921381
    NCBI Gene: 74131
Location & Maps
more
  • Sequence Map
    ChrX:48146436-48161565 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15130 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SASH3, SAM and SH3 domain containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SASH3, SAM and SH3 domain containing 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    753P9, CXorf9, HACS2, SH3D6C, SLY
  • Links
    NCBI Gene ID: 54440
    neXtProt AC: NX_O75995

  • Chr Location
    Xq26; chrX:129779916-129795201 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10362
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SASH3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
Mice homozygous for a truncation allele exhibit decreased T and B cells, altered B cell physiology and increased length of semi-identical allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017509 VEGA Gene Model | MGI Sequence Detail 15130 C57BL/6J ±  kb
transcript OTTMUST00000042517 VEGA | MGI Sequence Detail 2677 Not Applicable  
polypeptide OTTMUSP00000019111 VEGA | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    90 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 3
Other
Accession IDs
less
MGI:2148010
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory