Sash3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sash3
SAM and SH3 domain containing 3
MGI:1921381

24 phenotypes from 1 allele in 1 genetic background

Allelic Composition Genetic Background	Annotated Term	Reference
Sash3^tm1Hlz/Sash3^tm1Hlz B6.129P2-Sash3^tm1Hlz	abnormal B cell morphology	J:102171
	abnormal B cell physiology	J:102171
	abnormal CD4-positive T cell differentiation	J:102171
	abnormal CD8-positive, alpha-beta T cell differentiation	J:102171
	abnormal humoral immune response	J:102171
	abnormal immune system organ morphology	J:102171
	abnormal inflammatory response	J:102171
	abnormal marginal zone B cell physiology	J:102171
	abnormal T cell morphology	J:102171
	decreased double-positive T cell number	J:102171
	decreased IgG1 level	J:102171
	decreased IgG2a level	J:102171
	decreased IgG level	J:102171
	decreased IgM level	J:102171
	decreased interferon-gamma secretion	J:102171
	decreased interleukin-2 secretion	J:102171
	decreased interleukin-4 secretion	J:102171
	decreased interleukin-10 secretion	J:102171
	decreased marginal zone B cell number	J:102171
	decreased Peyer's patch number	J:102171
	decreased T cell proliferation	J:102171
	decreased tumor necrosis factor secretion	J:102171
	increased length of allograft survival	J:102171
	lymphoid hypoplasia	J:102171

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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