About   Help   FAQ
Arsg Gene Detail
Summary
  • Symbol
    Arsg
  • Name
    arylsulfatase G
  • Synonyms
    6330406P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921258
    NCBI Gene: 74008
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109364200-109464156 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 71.98 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921258
protein coding gene Chr11:109364159-109464156 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019335
protein coding gene Chr11:113039478-113140355 (+)
A/J MGP_AJ_G0019303
protein coding gene Chr11:108144017-108246126 (+)
AKR/J MGP_AKRJ_G0019272
protein coding gene Chr11:111386038-111496319 (+)
BALB/cJ MGP_BALBcJ_G0019277
protein coding gene Chr11:108576015-108676781 (+)
C3H/HeJ MGP_C3HHeJ_G0019086
protein coding gene Chr11:111693487-111797131 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019727
protein coding gene Chr11:116461128-116566550 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017350
protein coding gene Chr11:105372266-105469912 (+)
CAST/EiJ MGP_CASTEiJ_G0018639
protein coding gene Chr11:112822862-112931972 (+)
CBA/J MGP_CBAJ_G0019055
protein coding gene Chr11:121276704-121383876 (+)
DBA/2J MGP_DBA2J_G0019167
protein coding gene Chr11:107621636-107721026 (+)
FVB/NJ MGP_FVBNJ_G0019158
protein coding gene Chr11:107110231-107211794 (+)
LP/J MGP_LPJ_G0019237
protein coding gene Chr11:113445435-113551079 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019189
protein coding gene Chr11:120417173-120522466 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019764
protein coding gene Chr11:111951328-112059042 (+)
PWK/PhJ MGP_PWKPhJ_G0018404
protein coding gene Chr11:108785095-108890914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018196
protein coding gene Chr11:111737889-111838491 (+)
WSB/EiJ MGP_WSBEiJ_G0018691
protein coding gene Chr11:111879835-111982671 (+)



Homology
more
  • Human Ortholog
    ARSG, arylsulfatase G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARSG, arylsulfatase G
  • Synonyms
    USH4
  • Links
    NCBI Gene ID: 22901
    neXtProt AC: NX_Q96EG1
    UniProt: Q96EG1

  • Chr Location
    17q24.2; chr17:68259089-68452000 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Arsg mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display lysosomal storage pathology in the nervous system and peripheral tissues, including the liver and kidneys, resulting in Purkinje cell loss and age dependent cognitive impairment. Mice show a progressive degeneration of photoreceptor cells with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020604 Ensembl Gene Model | MGI Sequence Detail 99957 C57BL/6J ±  kb
    transcript ENSMUST00000020928 Ensembl | MGI Sequence Detail 3273 Not Applicable  
    polypeptide ENSMUSP00000020928 Ensembl | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144289
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:287257 Ingham NJ, et al., Functional analysis of candidate genes from genome-wide association studies of hearing. Hear Res. 2020 Mar 1;387:107879

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/05/2021
    MGI 6.17
    The Jackson Laboratory