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Arsg Gene Detail
Summary
  • Symbol
    Arsg
  • Name
    arylsulfatase G
  • Synonyms
    6330406P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921258
    NCBI Gene: 74008
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:109473374-109573330 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      99957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 71.98 cM, cytoband E1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ARSG, arylsulfatase G
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARSG, arylsulfatase G
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 22901
    neXtProt AC: NX_Q96EG1
    UniProt: Q96EG1

  • Chr Location
    17q24.2; chr17:68259089-68452000 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Arsg mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display lysosomal storage pathology in the nervous system and peripheral tissues, including the liver and kidneys, resulting in Purkinje cell loss and age dependent cognitive impairment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003356 VEGA Gene Model | MGI Sequence Detail 99957 C57BL/6J ±  kb
    transcript OTTMUST00000007054 VEGA | MGI Sequence Detail 3232 Not Applicable  
    polypeptide OTTMUSP00000003359 VEGA | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      584 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144289
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:254592 Kruszewski K, et al., Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1120-31

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory