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Arsg
Gene Detail
Symbol

Name
ID
Arsg
arylsulfatase G
MGI:1921258
Synonyms
6330406P08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
71.98 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:109473374-109573330 bp, + strand
From VEGA annotation of GRCm38

  99957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8978  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARSG
Protein SuperFamily: arylsulfatase-like protein
Gene Tree: Arsg

Human
homologs
ARSG, Arylsulfatase G
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 22901
neXtProt AC: NX_Q96EG1

Human Chr (Location): 17q24.2; chr17:68257159-68450773 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(21) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display lysosomal storage pathology in the nervous system and peripheral tissues, including the liver and kidneys, resulting in Purkinje cell loss and age dependent cognitive impairment.
 
Phenotype Images(3)
Interactions
Arsg interacts with 102 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process metabolic process, sulfur compound metabolic process
Component endoplasmic reticulum, extracellular space, ...
Function alkyl sulfatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (81)    Tissues (17)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 81
cDNA source data(27)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000003356 (Evidence)
Ensembl Gene Model ENSMUSG00000020604 (Evidence)
Entrez Gene 74008 (Evidence)
UniGene 482224
DFCI TC1581989, TC1684907
NIA Mouse Gene Index U040761
EC 3.1.6.-
Consensus CDS Project CCDS25581.1, CCDS48971.1
International Mouse Phenotyping Consortium Status Arsg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003356 VEGA Gene Model | MGI Sequence Detail 99957 C57BL/6J ±  kb
transcript OTTMUST00000007054 VEGA | MGI Sequence Detail 3232 Not Applicable 
polypeptide OTTMUSP00000003359 VEGA | MGI Sequence Detail 525 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(480 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000004326 arylsulfatase G
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219407 Kowalewski B, et al., Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III). Hum Mol Genet. 2015 Apr 1;24(7):1856-68
All references(38)
Other
accession IDs
MGI:2144289

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory