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Arsgtm1Tdi
Targeted Allele Detail
Summary
Symbol: Arsgtm1Tdi
Name: arylsulfatase G; targeted mutation 1, Thomas Dierks
MGI ID: MGI:5430640
Gene: Arsg  Location: Chr11:109364200-109464156 bp, + strand  Genetic Position: Chr11, 71.98 cM, cytoband E1
Alliance: Arsgtm1Tdi page
Lysosomal storage and cellular alterations in the CNS of Arsgtm1Tdi/Arsgtm1Tdi mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185592
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by insertion of a neo cassette. RT-PCR confirmed the absence of mRNA expression in homozygous mice. (J:185592)
Generation of the Arsgtm1Tdi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arsg Mutation:  29 strains or lines available
References
Original:  J:185592 Kowalewski B, et al., Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10310-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory